The Association Between Erectile Dysfunction and Depressive Symptoms in Men Treated for Prostate Cancer
The Association Between Erectile Dysfunction and Depressive Symptoms in Men Treated for Prostate Cancer
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DOI：
10.1111/j.1743-6109.2010.02127.x
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发表时间：
2011-02-01
影响因子：
3.5
通讯作者：
Roth, Andrew J.
中科院分区：
文献类型：
--
作者：
Nelson, Christian J.;Mulhall, John P.;Roth, Andrew J.
介绍。勃起功能障碍（ED）与抑郁症状之间的关系已经得到了很好的证实。然而，这种关系在前列腺癌患者中还没有得到很好的研究。有限的数据表明，与没有前列腺癌的ED患者相比，患有前列腺癌的男性ED患者较少受到ED的困扰，这意味着ED和抑郁症状可能与前列腺癌男性患者无关。主要结果测量。生活质量（癌症治疗功能评估[FACT-P]）、焦虑/抑郁（医院焦虑抑郁量表[HADS]）和勃起功能的评估。勃起功能的测量采用了FACT-P问卷中的一个问题，与马萨诸塞州男性衰老研究中使用的问题类似。方法：前列腺癌患者和未接受激素治疗的男性在一个时间点完成研究问卷。结果：339名男性的平均年龄为67±10岁。平均诊断时间为3.9±3年。当回答“我能够勃起并保持勃起”这个问题时，在1到5的范围内（5代表最佳功能），平均得分为2，表示“一点点”。单因素分析显示，勃起功能与抑郁相关，r = -0.12, P < 0.05。与抑郁相关的其他变量为婚姻状况，r = 0.11, P < 0.05；焦虑评分，r = 0.56, P < 0.01；社会支持，r = -0.42, P < 0.01。在多变量分析中，勃起功能仍然是抑郁症的显著预测因子，β = -0.10, P < 0.05。在单因素和多因素分析中，勃起功能障碍与抑郁症状相关，表明ED与抑郁症状独立相关，即使患者在诊断后大约4年。这些横断面数据表明，前列腺癌患者的ED可能会产生持久的心理影响。Nelson CJ， Mulhall JP和Roth AJ。前列腺癌患者勃起功能障碍与抑郁症状的关系性医学杂志2011；8:560-566。
Introduction.The relationship between erectile dysfunction (ED) and depressive symptoms is well established. However, this relationship is not well explored in men with prostate cancer. Limited data suggest men with prostate cancer may experience less ED bother than men with ED who do not have prostate cancer, implying that ED and depressive symptoms may not be associated in men with prostate cancer.Aim.To determine if ED is associated with depressive symptoms in men with prostate cancer.Main Outcome Measures.Assessments of quality-of-life (The Functional Assessment of Cancer Therapy [FACT-P]), anxiety/depression (Hospital Anxiety and Depression Scale [HADS]), and erectile function. Erectile function was measured with one question from the FACT-P similar to that used by the Massachusetts Male Aging Study.Methods.Men with prostate cancer, and naive of hormone treatment, completed the study questionnaires at a single time point.Results.The average age of the 339 men was 67 +/- 10 years. The average time since diagnosis was 3.9 +/- 3 years. When answering the question, "I am able to have and maintain an erection" on a 1 to 5 scale (5 representing the best function), the mean score was 2 indicating "a little bit." On univariate analysis, erectile function and depression were associated, r = -0.12, P < 0.05. Other variables associated with depression were marital status, r = 0.11, P < 0.05; anxiety scores, r = 0.56, P < 0.01; and social support, r = -0.42, P < 0.01. On multivariate analysis, erectile function remained a significant predictor of depression, beta = -0.10, P < 0.05.Conclusions.Erectile function was associated with depressive symptoms in both univariate and multivariate analysis, indicating that ED is independently associated with depressive symptoms even though patients were approximately 4 years post diagnosis. These cross-sectional data suggest ED in men with prostate cancer can have lasting psychological effects. Nelson CJ, Mulhall JP, and Roth AJ. The association between erectile dysfunction and depressive symptoms in men treated for prostate cancer. J Sex Med 2011;8:560-566.