Heme iron-based dietary intervention for improvement of iron status in young women
Heme iron-based dietary intervention for improvement of iron status in young women
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DOI：
10.1016/j.nut.2012.04.013
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发表时间：
2013-01-01
期刊：
影响因子：
4.4
通讯作者：
Hulthen, Lena
中科院分区：
文献类型：
--
作者：
Hoppe, Michael;Brun, Beatrice;Hulthen, Lena
目的：常规铁缺乏症的药物铁剂治疗往往会引起副作用。血红素铁具有高生物利用度和低能力，导致胃肠道副作用。本研究探讨了以血基脆面包的形式使用血红素铁作为饮食治疗方案来改善育龄妇女铁状况的可能性。（平均年龄24岁）被分配到四个组之一：血基脆面包（35毫克铁[Fe]，其中27毫克是血红素铁），铁补充剂包括35毫克非血红素铁/天（Fe 35），铁补充剂，包括60 mg非血红素铁/天（Fe 60）和对照组（不含铁的片剂）。脆面包组的身体铁显著增加，中位数为2.7 mg/kg（四分位距3.1，n = 18），Fe 35组为2.7 mg/kg（四分位距2.8，n = 11），Fe 60组为4.1 mg/kg（四分位距3.6，n = 13），而对照组未观察到变化。无统计学显着性差异，观察脆面包组与两个铁补充groups.Conclusion：饮食为基础的治疗含有血红素铁的副作用少，可以有效地用于改善育龄妇女的铁状况。(C)2013 Elsevier Inc. All rights reserved.
Objective: Conventional iron deficiency treatment with pharmacologic iron doses often causes side effects. Heme iron has high bioavailability and a low capacity to cause gastrointestinal side effects. This study investigated the possibility of using heme iron in the form of blood-based crisp bread as a diet-based treatment program to improve the iron status of women of reproductive age.Methods: In a 12-wk intervention study, 77 women (mean age 24 y) were assigned to one of four groups: blood-based crisp bread (35 mg of iron [Fe], 27 mg of which was heme Fe), iron supplementation consisting of 35 mg of non-heme iron/day (Fe35), iron supplementation consisting of 60 mg of non-heme iron/day (Fe60), and controls (iron-free tablets).Results: Body iron increased significantly in the crisp bread group by a median of 2.7 mg/kg (interquartile range 3.1, n = 18), in the Fe35 group by 2.7 mg/kg (interquartile range 2.8, n = 11), and in the Fe60 group by 4.1 mg/kg (interquartile range 3.6, n = 13), whereas no change was observed in the control group. No statistically significant difference in iron status increase was observed between the crisp bread group compared with the two iron-supplemented groups.Conclusion: Dietary-based treatment containing heme iron has few side effects and can be used efficiently to improve the iron status of women of reproductive age. (C) 2013 Elsevier Inc. All rights reserved.