Acute psychological and physiological effects of MDMA ("Ecstasy") after haloperidol pretreatment in healthy humans
Acute psychological and physiological effects of MDMA ("Ecstasy") after haloperidol pretreatment in healthy humans
复制标题
DOI：
10.1016/s0924-977x(00)00086-9
复制
发表时间：
2000-07-01
影响因子：
5.6
通讯作者：
Vollenweider, FX
中科院分区：
文献类型：
--
作者：
Liechti, ME;Vollenweider, FX
3，4-亚甲基二氧基甲基苯丙胺(MDMA，“摇头丸”)释放5-羟色胺和多巴胺。多巴胺在调节MDMA效应中的作用尚未在人类身上得到检验。我们观察了多巴胺D-2拮抗剂氟哌啶醇(1.4 mg，i.v.)MDMA(1.5 mg/kg P.O.)对心理生理反应的影响在14名健康志愿者中，采用双盲安慰剂对照受试者设计。主观峰值效应用标准化的量表进行分级。测量的生理效应是血压、心率和体温。在治疗期间、治疗1天和3天后评估副作用。氟哌啶醇可减弱MDMA诱导的积极和躁狂样情绪，但对其他主观变化或心血管效应没有减少作用。结果与MDMA兴奋效应的部分多巴胺能中介是一致的。相比之下，多巴胺似乎对MDMA的生理效应没有贡献，这表明了5-羟色胺和去甲肾上腺素的作用。(C)2000年，爱思唯尔科学公司出版。
3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") releases serotonin and dopamine. The role for dopamine in mediating the effects of MDMA has not yet been examined in humans. We investigated the effect of pretreatment with the dopamine D-2 antagonist haloperidol (1.4 mg i.v.) on psychological and physiological responses to MDMA (1.5 mg/kg p.o.) in 14 healthy volunteers using a double-blind placebo-controlled within-subject design. Subjective peak effects were rated using standardised scales. The physiological effects measured were blood pressure, heart rate and body temperature. Side effects were assessed during the session, and after 1 and 3 days. Haloperidol attenuated MDMA-induced positive and mania-like mood but had no reducing effect on other subjective changes or on cardiovascular effects. Results are consistent with a partial dopaminergic mediation of the euphoriant effects of MDMA. In contrast, dopamine does not seem to contribute to the physiological effects of MDMA, indicating a role for serotonin and norepinephrine. (C) 2000 Published by Elsevier Science B.V.