Cortical excitability and sleep deprivation: a transcranial magnetic stimulation study
Cortical excitability and sleep deprivation: a transcranial magnetic stimulation study
复制标题
DOI：
10.1136/jnnp.71.6.809
复制
发表时间：
2001-12-01
影响因子：
11
通讯作者：
Cantello, R
中科院分区：
文献类型：
--
作者：
Civardi, C;Boccagni, C;Cantello, R
目的是评估正常受试者睡眠剥夺后皮质兴奋性的变化。睡眠不足会以一种未知的方式激活脑电癫痫样活动。经颅磁刺激(TMS)可以告知初级运动皮质的兴奋性。研究对象为8名健康受试者(男4名，女4名)。在右侧第一骨间背侧肌肉的“热点”处，通过初级运动皮质上的焦点线圈进行经颅磁刺激(单次和成对)。测定了以下运动诱发电位特征：(A)刺激的活动和静息阈值；(B)静止期的持续时间；(C)在刺激间隔2和3ms时，皮层内对成对TM的抑制量；在刺激间隔14和16INS时，易化量。在至少24小时的睡眠剥夺后，重复整个TMS会话。睡眠剥夺后，对刺激的阈值(活跃肌和静止肌)以及静止期没有明显变化。相比之下，配对刺激研究显示出显著的(p
The objective was to assess the changes in cortical excitability after sleep deprivation in normal subjects. Sleep deprivation activates EEG epileptiform activity in an unknown way. Transcranial magnetic stimulation (TMS) can inform on the excitability of the primary motor cortex. Eight healthy subjects (four men and four women) were studied. Transcranial magnetic stimulation (single and paired) was performed by a focal coil over the primary motor cortex, at the "hot spot" for the right first dorsal interosseous muscle. The following motor evoked potential features were measured: (a) active and resting threshold to stimulation; (b) duration of the silent period; (c) amount of intracortical inhibition on paired TMS at the interstimulus intervals of 2 and 3 ms and amount of facilitation at interstimulus intervals of 14 and 16 ins. The whole TMS session was repeated after a sleep deprivation of at least 24 hours. After the sleep deprivation, the threshold to stimulation (in the active and resting muscle), as well as the silent period, did not change significantly. By contrast, the paired stimulus study showed a significant (p