Optimizing an 18F-NaF and 18F-FDG cocktail for PET assessment of metastatic castration-resistant prostate cancer.
Optimizing an 18F-NaF and 18F-FDG cocktail for PET assessment of metastatic castration-resistant prostate cancer.
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优化 18F-NaF 和 18F-FDG 混合物，用于转移性去势抵抗性前列腺癌的 PET 评估。
DOI：
10.1097/mnm.0000000000000383
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发表时间：
2015
影响因子：
1.5
通讯作者：
Jeraj,Robert
中科院分区：
文献类型：
--
作者：
Simoncic,Urban;Perlman,Scott;Liu,Glenn;Jeraj,Robert
背景应用氟化钠/2-（18 F）-氟-2-脱氧-D-葡萄糖（18 F-NaF/18 F-FDG）混合液进行PET/CT显像已被推荐用于骨转移瘤患者。这项工作的目的是优化的鸡尾酒组合物为转移性去势抵抗性前列腺癌（mCRPC）的患者。材料和methodsThe研究进行了6例mCRPC患者，共26个分析病变。患者在不同的时间点注射18F-NaF和18F-FDG。动态PET/CT成像记录两种示踪剂进入骨转移瘤的摄取时间过程。通过动力学分析将18 F-NaF和18 F-FDG摄取解耦，这使得能够计算18 F-NaF和18 F-FDG标准化摄取值（SUV）图像。评价示踪剂和所有可见病变的峰值、平均值和总SUV。在两种示踪剂对成像的贡献相等的假设下，对18 F-NaF/18 F-FDG混合物进行了优化。18F-NaF和18F-FDG的PET/CT联合成像的SUV图像由18F-NaF：18F-FDG比例为1：8~1：2的混合物组成。结果18F-NaF的峰值和平均SUV平均比18F-FDG的峰值和平均SUV高4~5倍，病变间变异系数为20%。18F-NaF的总SUV平均比18F-FDG高7倍。当18 F-NaF：结论当18 F-NaF：18 F-FDG比例为1：5时，混合液中18 F-NaF和18 F-FDG对PET显像的贡献相当。因此，我们建议将该比例作为mCRPC患者的最佳鸡尾酒组成。我们还敦促在任何18 F-NaF/18 F-FDG混合物PET/CT检查中严格控制混合物成分。
BackgroundPET/computed tomography (CT) imaging with the sodium-(18 F)-fluoride/2-(18 F)-fluoro-2-deoxy-D-glucose (18 F-NaF/18 F-FDG) cocktail has been proposed for patients with osseous metastases. This work aimed to optimize the cocktail composition for patients with metastatic castration-resistant prostate cancer (mCRPC).Materials and methodsThe study was carried out on six patients with mCRPC, with a total of 26 analyzed lesions. The patients were injected with 18 F-NaF and 18 F-FDG at separate time points. Dynamic PET/CT imaging recorded the uptake time course for both the tracers into osseous metastases. 18 F-NaF and 18 F-FDG uptakes were decoupled by kinetic analysis, which enabled calculation of 18 F-NaF and 18 F-FDG standardized uptake values (SUVs) images. Peak, mean, and total SUVs were evaluated for both tracers and all visible lesions. The 18 F-NaF/18 F-FDG cocktail was optimized under the assumption that the contribution of both tracers to image formation is equal. SUV images from PET/CT imaging with a combination of 18 F-NaF and 18 F-FDG were generated for cocktail compositions with an 18 F-NaF: 18 F-FDG ratio varying from 1: 8 to 1: 2.ResultsThe 18 F-NaF peak and mean SUVs were on average four to five times higher than the 18 F-FDG peak and mean SUVs, with an interlesion coefficient of variations of 20%. The total SUV for 18 F-NaF was on average seven times higher than that for 18 F-FDG. When the 18 F-NaF: 18 F-FDG ratio changed from 1: 8 to 1: 2, the typical SUV on the generated PET images increased by 50%, whereas the change in the uptake visual pattern was hardly noticeable.Conclusion18 F-NaF and 18 F-FDG in the cocktail contribute equally to image formation when the 18 F-NaF: 18 F-FDG ratio is 1: 5. Therefore, we propose this ratio as the optimal cocktail composition for mCRPC patients. We also urge to strictly control the cocktail composition during any 18 F-NaF/18 F-FDG cocktail PET/CT examination.