Ontogeny of the renal response to natriuretic peptide in sheep.
Ontogeny of the renal response to natriuretic peptide in sheep.
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绵羊肾脏对利尿钠肽反应的个体发育。
DOI：
10.1152/ajprenal.1988.254.5.f634
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
VanOrden,DE
中科院分区：
文献类型：
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作者：
Robillard,JE;Nakamura,KT;Varille,VA;Andresen,AA;Matherne,GP;VanOrden,DE
在长期仪器胎儿，新生儿和成年非妊娠绵羊中研究了持续全身输注心钠素（ANP）对肾脏反应的个体发生。在低速率（0.025 μ g·kg-1·min-1）和高速率（0.1 μ g·kg-1·min-1）ANP输注期间，各组动物的血浆免疫反应性ANP（ANPir）浓度相似。结果表明，胎羊和新生羔羊在输注心钠素（ANP）时，肾血流速度（RBFV）下降，肾血管阻力（RVR）升高。在高ANP输注速率期间，胎儿（-28.5 +/- 8.5和93 +/- 6.4%）的RBFV和RVR的百分比变化显著（P <0.05）大于成年绵羊（-6.6 +/- 3.2和-4.4 +/- 4.9%）。ANP对胎儿尿流量（V）无明显影响，但使新生羔羊和成年绵羊的V显著增加。成年绵羊输注ANP时肾小球滤过率显著增加，但胎羊和新生羔羊的肾小球滤过率无显著变化。在高ANP输注速率期间，成年绵羊（3，520 +/-2，414%）尿钠排泄率（UNaV）的百分比变化显著高于新生绵羊（157 +/- 106%）和胎羊（198 +/- 84%）。这些结果表明，在成熟期间，对连续ANP输注的心血管、肾脏血流动力学以及可能的肾功能反应增加，成年动物的总体反应更大。
The ontogeny of the renal response to continuous systemic infusion of atrial natriuretic peptide (ANP) was studied in chronically instrumented fetal, newborn, and adult nonpregnant sheep. Plasma immunoreactive ANP (ANPir) concentrations during low (0.025 microgram.kg-1.min-1) and high rate (0.1 microgram.kg-1.min-1) ANP infusion were similar between each group of animals. Decrease in renal blood flow velocity (RBFV) and rise in renal vascular resistance (RVR) were observed in fetal and newborn lambs during ANP infusion. The percent changes in RBFV and RVR were of significantly (P less than 0.05) greater magnitude during high ANP infusion rate in fetuses (-28.5 +/- 8.5 and 93 +/- 6.4%) than in adult sheep (-6.6 +/- 3.2 and -4.4 +/- 4.9%). ANP produced no changes in urine flow (V) in fetuses but increased V significantly in newborn lambs and adult sheep. Glomerular filtration rate increased significantly during ANP infusion in adult sheep but not in fetal and newborn lambs. Percentage changes in urinary excretion rate of Na (UNaV) during high ANP infusion rate were significantly higher in adult sheep (3,520 +/- 2,414%) than in newborn (157 +/- 106%) and fetal lambs (198 +/- 84%). These results suggest that the cardiovascular, renal hemodynamic, and possibly renal function responses to continuous ANP infusion increase during maturation, the overall response being larger in adult animals.