Cone receptor variations and their functional consequences in two species of hamster
Cone receptor variations and their functional consequences in two species of hamster
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DOI：
10.1017/s0952523899161029
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发表时间：
1999-01-01
影响因子：
1.9
通讯作者：
Jacobs, GH
中科院分区：
文献类型：
--
作者：
Calderone, JB;Jacobs, GH
早期实验的结果表明，不同种类的啮齿动物在视网膜中发现的视锥类型的数量和视锥色素的光谱灵敏度方面都不同。这些特征现在已经在两种通常用于研究目的的仓鼠中进行了研究：叙利亚金黄仓鼠（Mesocricetus auratus）和西伯利亚侏儒仓鼠（Photopus sungorus）。本研究采用视网膜电图（ERG）闪烁光度法、行为辨别任务和视蛋白抗体标记法研究仓鼠的光感受器及其视觉后果。三种方法的结果支持以下结论：（1）两种物种的视网膜都有大量的含有色素的视杆细胞，其峰值敏感度约为498-500 nm;（2）西伯利亚矮仓鼠有两类视锥细胞：一类在紫外线（c.（3）叙利亚金仓鼠具有一类视锥，其峰值灵敏度在506 nm附近，但缺乏第二类视锥。这些替代安排的影响进行了讨论。
Results from earlier experiments indicate that different species of rodent vary both in the number of cone types found in their retinas and in the spectral sensitivities of the cone pigments. These features have now been examined in two types of hamster commonly used for research purposes: Syrian golden hamsters (Mesocricetus auratus) and Siberian dwarf hamsters (Phodopus sungorus). Electroretinogram (ERG) flicker photometry, behavioral discrimination tasks, and opsin antibody labeling were used to investigate hamster photoreceptors and their visual consequences. Results from the three approaches support the following conclusions: (1) The retinas of both species have an abundant population of rods containing a photopigment with peak sensitivity of about 498-500 nm; (2) Siberian dwarf hamsters have two classes of cone: one with maximum sensitivity in the ultraviolet (c. 360 nm), the other with peak sensitivity closely similar to that of its rod; and (3) Syrian golden hamsters have a class of cone with peak sensitivity at about 506 nm, but they lack a second cone type. Implications of these alternative arrangements are discussed.