Total and lipid-associated serum sialic acid levels in cancer patients with different primary sites and differing degrees of metastatic involvement.
Total and lipid-associated serum sialic acid levels in cancer patients with different primary sites and differing degrees of metastatic involvement.
复制标题
不同原发部位和不同转移程度的癌症患者的总唾液酸和脂质相关血清唾液酸水平。
DOI：
10.1002/1097-0142(19861215)58:12
复制
发表时间：
1986
期刊：
影响因子：
6.2
通讯作者：
Alhadeff,JA
中科院分区：
文献类型：
--
作者：
Plucinsky,MC;Riley,WM;Prorok,JJ;Alhadeff,JA
由于恶性细胞中的碳水化合物畸变，血清总唾液酸（TSA）和脂质相关唾液酸（LASA）水平引起了相当大的关注。目前的调查确定了TSA，LASA，总蛋白（TP），TSA/TP值为171例癌症患者的各种原发部位和不同程度的转移性疾病，102例非恶性疾病（病理对照），和42名正常人。数据分析表明，（p < 0.01）癌症患者的平均（±SD）TSA和TSA/TP值增加（78.1 ± 19.2 mg/dl和12.4 ± 3.8 mg/g，和病理对照组（76.0 ± 7.5 mg/dl和11.6 ± 2.5 mg/g）（67.3 ± 7.1 mg/dl和9.0 ± 1.1 mg/g），癌症患者的平均TP值显著降低（6.4 ± 1.1 g/dl）和病理对照（6.6 ± 1.1 g/dl）相比，正常对照（7.5 ± 0.5 g/dl）。两组间LASA值无显著差异。进一步分析患者亚组的数据，根据所涉及的组织，具体的疾病，或恶性肿瘤的严重程度表明，缺乏特异性的标志物主要是由于有限的亚组，TSA和TSA/TP的敏感性增加，恶性肿瘤变得更严重。结果表明TSA/TP是检测恶性肿瘤最有用的标志物。该标记物应被证明可用于监测恶性疾病复发和/或进展，并用于评估各种治疗方法的有效性。
Serum total sialic acid (TSA) and lipid‐associated sialic acid (LASA) levels have drawn considerable interest because of carbohydrate aberrations in malignant cells. The current investigation determined the TSA, LASA, total protein (TP), and TSA/TP values for 171 cancer patients with various primary sites and differing degrees of metastatic disease, 102 patients with nonmalignant diseases (pathologic controls), and 42 normal individuals. Data analysis indicated significant (p < 0.01) increases in the mean (±SD) TSA and TSA/TP values in the cancer patients (78.1 ± 19.2 mg/dl and 12.4 ± 3.8 mg/g, respectively) and in the pathologic controls (76.0 ± 7.5 mg/dl and 11.6 ± 2.5 mg/g) when compared to the normal controls (67.3 ± 7.1 mg/dl and 9.0 ± 1.1 mg/g), and a significant decrease in the mean TP values in the cancer patients (6.4 ± 1.1 g/dl) and pathologic controls (6.6 ± 1.1 g/dl) when compared to normal controls (7.5 ± 0.5 g/dl). No significant difference was observed between groups in LASA values. Further analysis of the data in patient subgroups based on the tissue involved, specific disease, or severity of the malignancy indicated that the lack of specificity of the markers was due primarily to restricted subgroups and that the sensitivity of TSA and TSA/TP increased as the malignancy became more severe. The results show that TSA/TP was the most useful of the markers tested for detecting malignancies. This marker should prove useful for monitoring malignant disease recurrence and/or progression and for evaluating the effectiveness of various therapeutic approaches.