Association of-308G/A polymorphism in the tumor necrosis factor-α gene promoter with susceptibility to development of hantavirus cardiopulmonary syndrome in the Ribeiro Preto region, Brazil
Association of-308G/A polymorphism in the tumor necrosis factor-α gene promoter with susceptibility to development of hantavirus cardiopulmonary syndrome in the Ribeiro Preto region, Brazil
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DOI：
10.1007/s00705-010-0655-7
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发表时间：
2010-06-01
影响因子：
2.7
通讯作者：
Moraes Figueiredo, Luiz Tadeu
中科院分区：
文献类型：
--
作者：
Borges, Alessandra Abel;Donadi, Eduardo Antonio;Moraes Figueiredo, Luiz Tadeu
汉坦病毒心肺综合征（HCPS）中免疫反应的激活导致高TNF产生，这可能是导致该疾病的原因。多态性TNF 2等位基因（TNF-308 G/A）与细胞因子产生增加相关。我们调查了巴西患者中TNF 2等位基因与汉坦病毒感染结果的关系。共研究了122名汉他病毒暴露个体（26名呈现HCPS，96名仅汉他病毒血清转换）。与汉坦病毒血清学阳性但无HCPS病史的个体相比，HCPS患者中TNF 2等位基因更常见，这表明TNF 2等位基因可能是发生HCPS的危险因素。
Activation of the immune response in hantavirus cardiopulmonary syndrome (HCPS) leads to a high TNF production, probably contributing to the disease. The polymorphic TNF2 allele (TNF -308G/A) has been associated with increased cytokine production. We investigated the association of the TNF2 allele with the outcome of hantavirus infection in Brazilian patients. A total of 122 hantavirus-exposed individuals (26 presenting HCPS and 96 only hantavirus seroconversion) were studied. The TNF2 allele was more frequently found in HCPS patients than in individuals with positive serology for hantavirus but without a history of HCPS illness, suggesting that the TNF2 allele could represent a risk factor for developing HCPS.