Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats
Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats
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DOI：
10.1016/j.febslet.2007.03.029
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发表时间：
2007-04-17
期刊：
影响因子：
3.5
通讯作者：
Yatomi, Yutaka
中科院分区：
文献类型：
--
作者：
Kume, Yukio;Ikeda, Hitoshi;Yatomi, Yutaka
ADAMTS13正受到关注，因为它的缺乏会导致血栓性血小板减少性紫癜。虽然其调节机制尚未完全了解，但我们想知道肝星状细胞（HSC）是否发挥作用，因为ADAMTS13 mRNA仅在肝脏中表达，主要在HSC中表达。血浆ADAMTS13活性显着降低二甲基亚硝胺治疗的大鼠，其中HSC凋亡是一个重要的事件，但不是在四氯化碳或硫代乙酰胺治疗的大鼠没有HSC凋亡。此外，血浆ADAMTS13活性在70%肝切除大鼠中也降低，其中发生HSC损失。这些结果表明，HSC可能参与了血浆ADAMTS13活性的调节。(c)2007年欧洲生物化学学会联合会。Elsevier B.V.出版，保留所有权利。
ADAMTS13 is gaining attention, because its deficiency causes thrombotic thrombocytopenic purpura. Although its regulatory mechanism is not fully understood, we wondered if hepatic stellate cells (HSCs) play a role, because ADAMTS13 mRNA is exclusively expressed in the liver and primarily in HSCs. Plasma ADAMTS13 activity was markedly reduced in dimethylnitrosamine-treated rats, where HSC apoptosis is an essential event, but not in carbon tetrachloride- or thioacetamide-treated rats without HSC apoptosis. Furthermore, plasma ADAMTS13 activity was also reduced in 70% hepatectomized rats, where HSC loss occurs. These results suggest that HSC may be involved in the regulation of plasma ADAMTS13 activity. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.