Age, gender, and bone lamellae elastic moduli
Age, gender, and bone lamellae elastic moduli
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DOI：
10.1002/jor.1100180315
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发表时间：
2000-05-01
影响因子：
2.8
通讯作者：
Goldstein, SA
中科院分区：
文献类型：
--
作者：
Hoffler, CE;Moore, KE;Goldstein, SA
为了提高预防和治疗代谢性骨疾病和骨脆性疾病的策略，我们开始在细胞水平上探索骨组织的物理特性。从27具尸体（16名男性和11名女性）的股骨近端获取的力学性能的体外测量。我们测量了人骨中层状水平弹性模量和硬度随年龄和性别的变化，以确定与年龄和性别相关的机械完整性降低的微观结构特性。对外侧股骨颈进行检查，发现年龄、性别、身高、体重和体重指数与板层水平弹性模量或硬度无关。这一结果与骨细胞、间质和小梁组织一致。这些数据表明，已知发生在较重个体中的骨量维持增加并不伴随着板层水平弹性模量或硬度的增加。弹性模量和硬度与年龄和性别的独立性表明，与年龄和性别相关的机械完整性降低不涉及细胞外基质弹性模量或硬度的改变。还应研究层片级极限、疲劳和断裂韧性特性。其他因素，如组织质量和组织，也可能导致与年龄和性别相关的机械完整性降低。
To enhance preventative and therapeutic strategies fur metabolic bone diseases and bone fragility disorders, we began to explore the physical properties of bone tissue at the cellular level. Proximal femurs were harvested from 27 cadavera (16 male and 11 female) for in vitro measurement of the mechanical properties. We measured the variations in lamellar-level elastic modulus and hardness in human bone as a function of age and gender to identify microstructural properties responsible for age and gender-related reductions in the mechanical integrity. The lateral femoral necks were examined, and age, gender, height, body mass, and body mass index were not found to correlate with lamellar-level elastic modulus or hardness. This result was consistent for osteonal, interstitial, and trabecular tissue. These data suggest that increased bone mass maintenance, known to occur in heavier individuals, is not accompanied by increases in the lamellar-level elastic modulus or hardness. The independence of elastic modulus and hardness from age and gender suggests that age and gender-related decreases in mechanical integrity do not involve alterations in elastic modulus or hardness of the extracellular matrix. Lamellar-level ultimate, fatigue, and fracture toughness properties should also be investigated. Other factors, such as tissue mass and organization, may also contribute to age and gender-related decreases in the mechanical integrity.