A 3-D Hybrid Finite Element Model to Characterize the Electrical Behavior of Cutaneous Tissues
A 3-D Hybrid Finite Element Model to Characterize the Electrical Behavior of Cutaneous Tissues
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DOI：
10.1109/tbme.2009.2036371
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发表时间：
2010-04-01
影响因子：
4.6
通讯作者：
Gagnon, Herve
中科院分区：
文献类型：
--
作者：
Hartinger, Alzbeta E.;Guardo, Robert;Gagnon, Herve
皮肤的有限元建模对于研究皮肤组织的电特性和更好地理解皮肤内的电流分布是有用的。这种上皮有限元模型包括极薄的结构，如细胞膜、核膜和细胞外液。网格化这种狭窄的空间大大增加了元素的数量，导致更长的计算时间。这也大大减少了在达到计算极限之前可以组装的上皮细胞的数量。为了避免网格划分非常狭窄的空间，而不必要地增加元素的数量的问题，我们提出了一种新的混合建模方法来开发一个3-D有限元模型的皮肤。该皮肤模型包括所有皮肤层、不同病变类型和完整的电极模型。它用于分析正常和恶性皮肤组织的复杂电行为。该模型内的电流分布也进行了模拟，以评估在不同的工作频率下的电阻抗断层成像系统可实现的景深。
Finite element modeling of the skin is useful to study the electrical properties of cutaneous tissues and gain a better understanding of the current distribution within the skin. Such an epithelial finite element model comprises extremely thin structures like cellular membranes, nuclear membranes, and the extracellular fluid. Meshing such narrow spaces considerably increases the number of elements leading to longer computing time. This also greatly reduces the number of epithelial cells that can be assembled before reaching computing limitations. To avoid the problem of meshing extremely narrow spaces while unnecessarily increasing the number of elements, we present a new hybrid modeling approach to develop a 3-D finite element model of the skin. This skin model comprises all skin layers, different lesion types, and a complete electrode model. It is used to analyze the complex electrical behavior of normal and malignant skin tissues. The current distribution within this model is also simulated to assess the depth of field achievable by an electrical impedance tomography system at different operating frequencies.