Epidemiological study of oral allergy syndrome in birch pollen dispersal-free regions
Epidemiological study of oral allergy syndrome in birch pollen dispersal-free regions
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DOI：
10.1016/j.alit.2019.09.008
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发表时间：
2020-04-01
影响因子：
6.8
通讯作者：
Fujieda, Shigeharu
中科院分区：
文献类型：
--
作者：
Osawa, Yoko;Ito, Yumi;Fujieda, Shigeharu
背景资料：口腔变态反应综合征是由高度同源的共同抗原交叉反应引起的速发型变态反应（泛过敏原）所含的水果/蔬菜和花粉。方法：对6824名门诊就诊者进行问卷调查，检测血清抗粗抗原和泛抗原特异性IgE水平。在几乎没有传播的福井县，测定变应原成分，以研究OAS流行与花粉症之间的关系。结果：OAS的患病率为10.8%。OAS组的花粉症并发症发生率为67.4%，其中16.8%的患者出现OAS。致病食物的频率顺序是甜瓜，菠萝，猕猴桃，桃和苹果。来自OAS组的显著较高数量的患者对桦树、桤木和梯牧草特异性IgE呈阳性。OAS组花粉特异性IgE抗体阳性率明显高于对照组。在34例因吃苹果引起的OAS患者中，28例（82.4%）Mal d1特异性IgE阳性。在52例桃子诱导的OAS患者中，41例（78.8%）Pur p1特异性IgE阳性。粗抗原特异性IgE和抗PR-10组分特异性IgE之间的一致率分别为87.1%和93.3%的苹果和peach.Conclusions：在桦树花粉不分散的地区，OAS患者有一个显着的关联与Bet V1相关过敏的发病。抗PR-10组分IgE在诊断OAS中是有用的，并且粗抗原特异性IgE也与苹果和桃过敏相关。Copyright（C）2019，日本变态反应学会由爱思唯尔公司制作和主持
Background: Oral allergy syndrome (OAS) is an immediate allergy caused by a cross-reaction of highly homologous common antigens (pan-allergens) contained in fruits/vegetables and pollen.Methods: A questionnaire was provided to 6824 outpatient visitors and serum levels of specific IgEs against crude antigens and pan-allergen components were measured to study the relationship between the prevalence of OAS and pollinosis in the Fukui Prefecture where there is almost no dispersal of birch pollen.Results: The prevalence of OAS was 10.8%. The rate of pollinosis complication in the OAS group was 67.4%, and OAS was observed in 16.8% of pollinosis patients. Causative foods in order of frequency were melon, pineapple, kiwi fruit, peach, and apple. A significantly higher number of patients from the OAS group were positive for birch, alder, and timothy grass-specific IgE. The rate of positivity for anti-component IgE corresponding to pollen in OAS group was also significantly higher. Of 34 patients with OAS caused by eating apples, 28 (82.4%) were positive for Mal d1-specific IgE. Of the 52 patients with peach-induced OAS, 41 (78.8%) were positive for Pur p1-specific IgE. The concordance rates between crude antigen-specific IgE and anti-PR-10 component-specific IgE were 87.1% and 93.3% for apple and peach respectively.Conclusions: In regions where birch pollen is not dispersed, OAS patients have a significant association with the onset of Bet v1-associated allergy. Anti-PR-10 component IgE was useful in diagnosing OAS, and crude antigen-specific IgE was also associated with apple and peach allergies. Copyright (C) 2019, Japanese Society of Allergology. Production and hosting by Elsevier B.V.