Semiquantitative assessment of myelination using magnetic resonance imaging in normal fetal brains
Semiquantitative assessment of myelination using magnetic resonance imaging in normal fetal brains
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DOI：
10.1002/pd.873
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发表时间：
2004-05-01
影响因子：
3
通讯作者：
Kato, T
中科院分区：
文献类型：
--
作者：
Abe, S;Takagi, K;Kato, T
目的利用磁共振成像技术定量评价正常胎儿髓鞘形成与胎龄的关系。方法对101例妊娠26 ~ 39周无神经系统疾病的胎儿进行磁共振成像。感兴趣的区域被指定在额叶、辐射冠、视辐射、丘脑、脑桥、小脑蚓和玻璃体。通过每个指定区域的信号强度与玻璃体的信号强度计算信号强度比（SIR），并分析与GA的关系。结果脑额叶SIR与GA无显著性差异。日冕辐射和光辐射的SIR随GA的增加而显著降低（P < 0.05）；妊娠34周后，它们急剧下降。孕26周时，丘脑、脑桥和小脑蚓部的SIR显著小于脑白质（P < 0.05），随着GA的增加，SIR显著降低（P < 0.05）。结论：SIR的变化与先前组织病理学报告中髓鞘形成的时间进程大致相符。对MR图像进行半定量评估可用于产前诊断髓鞘形成的延迟或缺陷。版权所有：John Wiley Sons， Ltd. 2004
Objectives To evaluate the development of myelination in normal fetuses quantitatively using magnetic resonance (MR) imaging in relation to gestational age (GA).Methods Fetal MR images were obtained from 101 fetuses between 26 and 39 weeks of gestation with no neurological problems. Regions of interest were designated in frontal lobe, corona radiata, optic radiation, thalamus, pons, cerebellar vermis, and vitreous body. The signal intensity ratio (SIR) was calculated by the signal intensity of each of these designated areas to that of the vitreous body and analyzed in relation to GA.Results The SIR of the frontal lobe did not vary significantly with GA. The SIR of the corona radiata and the optic radiation decreased significantly with GA (P < 0.05); after 34 weeks of gestation, they decreased sharply. The SIR of the thalamus, the pons, and the cerebellar vermis was significantly smaller than that of the cerebral white matter at 26 weeks of gestation (P < 0.05) and decreased significantly with GA (P < 0.05).Conclusion Changes in the SIR approximately corresponded to the time-course of progression of myelination in the previous histopathological reports. Semiquantitative evaluation on MR images may allow prenatal diagnosis of a delay or deficit of myelination. Copyright (C) 2004 John Wiley Sons, Ltd.