MRI for identification of progression in brain tumors: from morphology to function.
MRI for identification of progression in brain tumors: from morphology to function.
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DOI：
10.1586/14737175.8.10.1507
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发表时间：
2008-10-01
影响因子：
4.3
通讯作者：
Stieltjes, Bram
中科院分区：
文献类型：
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作者：
Weber, Marc-Andre;Giesel, Frederik Lars;Stieltjes, Bram
对于脑肿瘤的监测，在随访期间早期识别进展或治疗失败以改变治疗方案并从而优化患者结局至关重要。在过去的几年中，磁共振（MR）领域的几个领域已经取得了相当大的进展：现代造影剂，先进的形态学方法和几种功能技术，例如，在肿瘤灌注或肿瘤细胞代谢的可视化。本文综述了这些最新进展，介绍了不同的技术，并概述了他们的好处，在脑肿瘤的进展识别，重点是胶质瘤，转移瘤和脑膜瘤。放疗后，磁共振波谱有助于更准确地区分放射性坏死和胶质瘤进展。在低级别胶质瘤中，灌注MR技术能够比常规MRI更灵敏地检测间变性转化。现代造影剂以及扩散张量成像可以改善肿瘤描绘和肿瘤扩展评估。我们还将强调这些技术的生物背景，其适用性和目前的局限性。总之，现代MRI技术已经发展，即将融入临床常规。
For monitoring of brain tumors, it is crucial to identify progression or treatment failure early during follow-up to change treatment schemes and, thereby, optimize patient outcome. In the past years, several areas within the field of magnetic resonance (MR) have seen considerable advances: modern contrast media, advanced morphologic approaches and several functional techniques, for example, in the visualization of tumor perfusion or tumor cell metabolism. This review presents these recent advances by introducing the different techniques and outlining their benefit for identification of progression in brain tumors, with a focus on gliomas, metastases and meningiomas. After radiotherapy, MR spectroscopy helps to more accurately discriminate between radiation necrosis and glioma progression. In low-grade gliomas, perfusion MR techniques enable a more sensitive detection of anaplastic transformation than conventional MRI. Modern contrast media, as well as diffusion tensor imaging, allow for an improved tumor delineation and assessment of tumor extension. We will also highlight the biological background of these techniques, their applicability and current limitations. In conclusion, modern MRI techniques have been developed that are on the doorstep to be integrated in clinical routine.