Two pharmacological types of cardiac slow Na+ channels as distinguished by verapamil.
Two pharmacological types of cardiac slow Na+ channels as distinguished by verapamil.
复制标题
维拉帕米可区分心脏慢钠通道的两种药理学类型。
DOI：
10.1016/0014-2999(74)90250-7
复制
发表时间：
1974
影响因子：
5
通讯作者：
N. Sperelakis
中科院分区：
文献类型：
--
作者：
M. McLean;K. Shigenobu;N. Sperelakis
将鸡胚心切碎置于外植体培养中，或将其分解置于细胞培养中。获得了不被1 mM Mn2+阻断的TTX不敏感的慢Na+通道。维拉帕米也未能阻断这些通道。相比之下，新鲜的年轻（3天大）完整的胚胎心脏具有被维拉帕米阻断的自然发生的缓慢Na+通道。这些发现表明缓慢Na+通道有两种药理类型；维拉帕米阻断了其中一种而不是另一种。
Old chick embryonic hearts were either minced and placed into explant cultured or disaggregated and placed into cell culture. TTX insensitive slow Na+channels were acquired which were not blocked by 1 mM Mn2+. Verapamil also failed to block these channels. In contrast, fresh young (3 day old) embryonic hearts left intact possess naturally occurring slow Na+channels which are blocked by verapamil. These findings suggest that there are two pharmacological types of slow Na+channels; verapamil blocks one type but not the other.