Ambulacrarian prototypical Hox and ParaHox gene complements of the indirect-developing hemichordate Balanoglossus simodensis
Ambulacrarian prototypical Hox and ParaHox gene complements of the indirect-developing hemichordate Balanoglossus simodensis
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DOI：
10.1007/s00427-009-0298-4
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发表时间：
2009-07-01
影响因子：
2.4
通讯作者：
Saiga, Hidetoshi
中科院分区：
文献类型：
--
作者：
Ikuta, Tetsuro;Miyamoto, Norio;Saiga, Hidetoshi
HOX基因及其进化姊妹基因ParaHox基因在动物中广泛分布。虽然已经预测到半角类和棘皮动物只有一组HOX基因和一组ParaHox基因，但目前还不清楚Hox8的同源基因是否在半角类中缺失，因此，关于半角类中HOX/ParaHox基因互补的共识尚未建立。在本研究中，我们克隆了12个HOX基因的完整或接近完整的编码序列，其中包括以前没有报道的Hox8的同源基因，以及最近发现的间接发育的橡子虫Balanoglossus simodensis的三个ParaHox基因。我们的数据表明，祖先半脊椎动物具有完整的原生动物原型Hox和ParaHox基因的互补，分别由12和3个成员组成。
The Hox genes and its evolutionary sister, the ParaHox genes, are widely distributed among animals. Although it has been expected that hemichordates and echinoderms have a single set of Hox genes and most likely a single set of ParaHox genes, it is not known whether the ortholog of Hox8 is absent in hemichordates, and in turn, consensus view about Hox/ParaHox gene complements in hemichordates has not been established. In this study, we isolated either complete or nearly complete coding sequences of 12 Hox genes, including the ortholog of the Hox8 that has not been reported in the previous studies, and three ParaHox genes from the recently discovered indirect-developing acorn worm, Balanoglossus simodensis. Our data suggest that the ancestral hemichordate had intact complements of ambulacrarian prototypical Hox and ParaHox genes, consisting of 12 and three members, respectively.