Critical role of androgen receptor in the postnatal period in male sexual behavior in rats.
Critical role of androgen receptor in the postnatal period in male sexual behavior in rats.
复制标题
雄激素受体在出生后对大鼠雄性性行为的关键作用。
DOI：
10.1016/j.neulet.2015.10.040
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发表时间：
2015
影响因子：
2.5
通讯作者：
Kawata M.
中科院分区：
文献类型：
--
作者：
Yamada S;Ooya M;Takanami K;Matsuda KI;Kawata M.
性腺激素在调节性二型行为的神经系统的组织中起发育作用。众所周知，在啮齿类动物的大脑中，围产期睾丸分泌的雄激素通过芳香化酶转化为雌激素，雌激素及其受体在脑结构和功能的男性化中起着关键作用。在围产期用雄激素受体（AR）拮抗剂氟替卡松治疗可抑制男性特异性脑结构和功能的发育，这表明通过AR的雄激素信号传导也会影响大脑的男性化。在这项研究中，我们调查了出生后的哪个阶段对大脑男性化中的雄激素信号至关重要。出生后时期被指定为出生后0-22天（PD），并分为阶段I（PD 0-7）、阶段II（PD 8-14）和阶段III（PD 15-22）。新生雄性大鼠在每个阶段皮下注射氟替卡松。成年后，通过对雄性性行为的分析，评价产后氟替卡松治疗对脑男性化的影响。与其他组相比，在第I和第II阶段连续抑制AR导致了插入率和射精频率的显著降低。在I、II或III期中的AR抑制未引起任何变化。AR抑制对坐骑行为无影响。这些结果表明，出生后前两周特定阶段的AR激活可能有助于大脑男性化，介导成年男性的性行为。
Gonadal hormones have a developmental role in organization of the nervous system that regulates sexually dimorphic behavior. It is well known that androgen secreted from testes in the perinatal period is converted to estrogen by aromatase in rodent brain, and that estrogen and its receptor play a pivotal role in masculinization of brain structure and function. Treatment with flutamide, an androgen receptor (AR) antagonist, during the perinatal period inhibits development of malespecific brain structure and function, suggesting that androgen signaling via AR also influences brain masculinization. In this study, we investigated which stage during the postnatal period is critical for androgen signaling in brain masculinization. The postnatal period was designated as postnatal days (PD) 0–22, and divided into stages I (PD 0–7), II (PD 8–14), and III (PD 15–22). Newborn male rats were given flutamide subcutaneously in each stage. After adulthood, the effects of postnatal flutamide treatment on brain masculinization were evaluated byanalysis of male sexual behavior. Continuous inhibition of AR throughout stages I and II caused a robust reduction of the intromission ratio and ejaculation frequency compared with other groups. AR inhibition in stage I, II, or III did not cause any change. AR inhibition had no effect onmount behavior. These results show that stage-specific AR activation in the first two postnatal weeks may contribute to brain masculinization mediating male sexual behavior in adulthood.