Effect of hydroxy groups and microtopography generated by a nanosecond-pulsed laser on pure Ti surfaces
Effect of hydroxy groups and microtopography generated by a nanosecond-pulsed laser on pure Ti surfaces
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DOI：
10.1007/s10856-019-6259-1
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发表时间：
2019-05
期刊：
影响因子：
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通讯作者：
Yuta Kurashina;A. Ezura;R. Murakami;M. Mizutani;J. Komotori
中科院分区：
文献类型：
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作者：
Yuta Kurashina;A. Ezura;R. Murakami;M. Mizutani;J. Komotori
在本文中，我们研究了一个过程中修改的表面微观形貌的钛氧化物层使用纳秒脉冲激光（NPL）。即使现在，在通过NPL处理的钛表面上产生羟基的机制也不清楚。因此，我们评估了纯钛表面上的NPL散焦距离的表面特性，并研究了羟基磷灰石/细胞活力的产生与钛表面特性之间的关系。NPL散焦距离从0到4 mm变化。0和2 mm的散焦距离在钛表面上产生微观形貌特征，并且所得表面表现出比用4 mm的散焦距离处理的表面更大的OH基团密度。使用0和2 mm的散焦距离处理的表面被发现被涂覆有由共存的板状和针状晶体浸泡在模拟体液后，碱性磷酸酶活性测定表明改善的细胞相容性。生物相容性和细胞相容性的改善是由于沿着加工轨迹形成的口袋状微观形貌结构。这些空穴中含有大量的羟基，促进了羟基磷灰石的生长。
In this paper, we study a process for modifying the surface microtopography of the Ti oxide layer using a nanosecond-pulsed laser (NPL). Even now, the mechanism by which hydroxyl groups are generated on the titanium surface treated by NPL is not clear. Hence, we evaluated the surface properties of the NPL defocus distances on pure titanium surfaces, and investigated the relationship between the generation of hydroxyapatites/cell viability and the titanium surface characteristics. The NPL defocus distance was varied from 0 to 4 mm. Defocus distances of 0 and 2 mm generated microtopographical features on the titanium surface, and the resulting surfaces exhibited a greater density of OH groups than the surface treated with a defocus distance of 4 mm. The surfaces treated using defocus distances of 0 and 2 mm were found to be coated with microspherical hydroxyapatite composed of coexisting plate- and needle-like crystals after immersion in simulated body fluid, and alkaline phosphatase activity assays indicated improved cell compatibility. The improvements in biocompatibility and cell compatibility were due to the pocket-like microtopographical structures formed along the processing trace. These pockets contained a large amount of OH groups, and promoted the growth of hydroxyapatite.