cgpPindel: Identifying Somatically Acquired Insertion and Deletion Events from Paired End Sequencing.
cgpPindel: Identifying Somatically Acquired Insertion and Deletion Events from Paired End Sequencing.
复制标题
DOI：
10.1002/0471250953.bi1507s52
复制
发表时间：
2015-12-17
影响因子：
--
通讯作者：
Campbell PJ
中科院分区：
文献类型：
--
作者：
Raine KM;Hinton J;Butler AP;Teague JW;Davies H;Tarpey P;Nik-Zainal S;Campbell PJ
cgpPindel是Pindel的修改版本，与参考对照相比，其被优化用于检测癌症基因组和其他样品中的体细胞插入和缺失（indel）。事后过滤器去除假阳性调用，从而产生用于下游分析的高质量数据集。本单元为cgpPindel的简单“一次性”执行和适合大规模计算场的更详细方法提供了简明的说明。
cgpPindel is a modified version of Pindel that is optimized for detecting somatic insertions and deletions (indels) in cancer genomes and other samples compared to a reference control. Post-hoc filters remove false positive calls, resulting in a high-quality dataset for downstream analysis. This unit provides concise instructions for both a simple ‘one-shot’ execution of cgpPindel and a more detailed approach suitable for large-scale compute farms.