Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies A Scientific Statement From the American Heart Association
Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies A Scientific Statement From the American Heart Association
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DOI：
10.1161/res.0000000000000169
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发表时间：
2017-09-01
影响因子：
20.1
通讯作者：
Virmani, Renu
中科院分区：
文献类型：
--
作者：
Daugherty, Alan;Tall, Alan R.;Virmani, Renu
动物研究是确定动脉粥样硬化机制和药物预防病变发展或逆转疾病的潜在靶点的基础。在目前的文献中，不同研究小组的动物研究结果相互矛盾是很常见的，导致缺乏对实验结果的外推来理解人类疾病。本声明旨在为动物研究中实验设计和解释的开发和执行提供指导原则。建议包括以下内容：（1）动物模型选择，以及对模拟人类疾病方面的保真度的评论;（2）实验设计及其对数据解释的影响;（3）提高动脉粥样硬化病变测量和表征准确性的标准方法。
Animal studies are a foundation for defining mechanisms of atherosclerosis and potential targets of drugs to prevent lesion development or reverse the disease. In the current literature, it is common to see contradictions of outcomes in animal studies from different research groups, leading to the paucity of extrapolations of experimental findings into understanding the human disease. The purpose of this statement is to provide guidelines for development and execution of experimental design and interpretation in animal studies. Recommendations include the following: (1) animal model selection, with commentary on the fidelity of mimicking facets of the human disease; (2) experimental design and its impact on the interpretation of data; and (3) standard methods to enhance accuracy of measurements and characterization of atherosclerotic lesions.