Brain vasopressin is an important regulator of maternal behavior independent of dams' trait anxiety
Brain vasopressin is an important regulator of maternal behavior independent of dams' trait anxiety
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DOI：
10.1073/pnas.0807412105
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发表时间：
2008-11-04
影响因子：
11.1
通讯作者：
Neumann, Inga D.
中科院分区：
文献类型：
--
作者：
Bosch, Oliver J.;Neumann, Inga D.
神经肽精氨酸加压素(AVP)可以说是迄今为止发现的对哺乳动物社会行为最有效的调节因素之一。然而，只有相关的神经肽催产素(OXT)被证明能促进母亲的行为。在这里，我们通过使用互补的药理学和遗传学方法来评估AVIP在母体护理中的作用，特别是在弓背哺育、取回幼崽和幼崽接触中的作用。此外，实验还在具有不同特质焦虑的大鼠模型中进行，即饲养高(HAB)或低(LAB)焦虑相关行为的大鼠以及非选择(NAB)模型的大鼠。病毒载体介导的AVP V1a受体(AVP-Rs)在哺乳期NAB大鼠视前内侧区上调，NAB和实验鼠的慢性中枢AVP治疗得到改善，但通过反义寡核苷酸或中枢性AVIP-R拮抗剂局部阻断AVP-R的表达，损害了NAB鼠的母爱。此外，在具有遗传决定的大脑AVP活性升高的HAB大鼠中，固有的高水平的产妇护理被阻断AVP-R作用而逆转。治疗导致的AVP介导的母体行为障碍增加了成人的情绪性，并损害了NAB DAMS雄性后代的社会互动。这些发现提供了直接证据，证明了大脑AVIP在促进母性行为方面发挥了重要和高度有效的作用，这似乎与母亲的特质焦虑无关。
The neuropeptide arginine vasopressin (AVP) is arguably among the most potent regulators of social behaviors in mammals identified to date. However, only the related neuropeptide oxytocin (OXT) has been shown to promote maternal behavior. Here, we assess the role of AVIP in maternal care, in particular in arched back nursing, pup retrieval, and pup contact by using complementary pharmacological and genetic approaches. Also, experiments were performed in rat dams with differences in trait anxiety, i.e., rats bred for either high (HAB) or low (LAB) anxiety-related behavior as well as nonselected (NAB) dams. Viral vector-mediated up-regulation of AVP V1a receptors (AVP-Rs) within the medial preoptic area of lactating NAB rats and chronic central AVP treatment of NAB and LAB dams improved, whereas local blockade of AVP-R expression by means of antisense oligodeoxynucleotides or central AVIP-R antagonism impaired, maternal care in NAB dams. Also, in HAB rats with a genetically determined elevated brain AVP activity, intrinsically high levels of maternal care were reversed by blockade of AVP-R actions. Treatment-induced impairment of AVP-mediated maternal behavior increased adult emotionality and impaired social interactions in male offspring of NAB dams. These findings provide direct evidence for an essential and highly potent role of brain AVIP in promoting maternal behavior, which seems to be independent of the dam's trait anxiety.