Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA-DQ (alpha 1*0501,beta 1*02) or the HLA-DQ (alpha 1*03,beta 1*0302) heterodimers
Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA-DQ (alpha 1*0501,beta 1*02) or the HLA-DQ (alpha 1*03,beta 1*0302) heterodimers
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DOI：
10.1111/j.1399-0039.1997.tb02706.x
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发表时间：
1997-01-01
期刊：
影响因子：
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通讯作者：
Thorsby, E
中科院分区：
文献类型：
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作者：
Spurkland, A;Ingvarsson, G;Thorsby, E
对50例疱疹样皮炎患者和290例健康献血员进行HLA-DRB 1、-DQA 1和-DQB 1基因分型。43名患者（86%）和72名对照（25%）携带编码DQ（α 1*0501，β 1*02）异源二聚体的基因。在其余7名患者中，6名（占所有患者的12%）携带编码DQ（α 1*03，β 1*0302）异二聚体的基因。这些HLA相关性与在乳糜泻患者中观察到的非常相似。因此，我们得出结论，疱疹样皮炎和乳糜泻是与非常相同的HLA-DQ α β异二聚体。
HLA-DRB1, -DQA1, and -DQB1 genomic typing of 50 patients with dermatitis herpetiformis and of 290 healthy blood donors was performed. Genes encoding the DQ (alpha 1*0501, beta 1*02) heterodimer were carried by 43 (86%) of the patients and 72 (25%) of the controls. Of the remaining seven patients six (12% of all the patients) carried genes encoding the DQ (alpha 1*03, beta 1*0302) heterodimer. These HLA associations are very similar to those observed in patients with celiac disease. We thus conclude that dermatitis herpetiformis and celiac disease are associated to the very same HLA-DQ alpha beta heterodimers.