Highly Regioselective Palladium-Catalyzed Carboxylation of Allylic Alcohols with CO2
Highly Regioselective Palladium-Catalyzed Carboxylation of Allylic Alcohols with CO2
复制标题
DOI：
10.1002/chem.201503359
复制
发表时间：
2015-11-09
影响因子：
4.3
通讯作者：
Sato, Yoshihiro
中科院分区：
文献类型：
--
作者：
Mita, Tsuyoshi;Higuchi, Yuki;Sato, Yoshihiro
在CO2气氛(1atm)下，以ZnEt2为化学计量转金属试剂，在PdCl2和PPh3的催化作用下，对各种烯丙醇进行了羧化反应。这种羧化反应以高度区域选择性的方式进行，主要得到支化的羧酸。由此得到的，-不饱和羧酸被成功地转化为光学活性丁内酯，这是(R)-巴氯芬的已知中间体。
Various allylic alcohols were carboxylated in the presence of a catalytic amount of PdCl2 and PPh3 using ZnEt2 as a stoichiometric transmetalation agent under a CO2 atmosphere (1atm). This carboxylation proceeded in a highly regioselective manner to afford branched carboxylic acids predominantly. The ,-unsaturated carboxylic acid thus obtained was successfully converted into an optically active -butyrolactone, a known intermediate of (R)-baclofen.