Genetic and molecular abnormalities in cholangiocarcinogenesis.
Genetic and molecular abnormalities in cholangiocarcinogenesis.
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DOI：
10.21873/anticanres.16345
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发表时间：
2009-04
影响因子：
2
通讯作者：
Alrawi SJ
中科院分区：
文献类型：
--
作者：
Hassid VJ;Orlando FA;Awad ZT;Tan D;Khoury T;Ahmed BH;Alrawi SJ
Cholangiocarcinomas are biliary tree neoplasms of cholangiocyte origin. Several clinical risk factors are associated with cholangiocarcinogenesis. During the last decade, there has been an increasing interest in the causative molecular mechanisms of cholangiocarcinoma because of its poor prognosis and the lack of effective therapies. A better understanding of cholangiocarcinoma tumor initiation, promotion, and progression, as well as neurotransmitter, neuroendocrine, and endocrine growth effects, may elucidate molecular targets for diagnostic and therapeutic purposes.
