The pancreatic islet: a micro-organ in control.
The pancreatic islet: a micro-organ in control.
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DOI：
10.32113/cellr4_20213_3093
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发表时间：
2021-01-01
期刊：
影响因子：
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通讯作者：
Berggren, P O
中科院分区：
文献类型：
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作者：
Abdulreda, M H;Berggren, P O
朗格汉斯的胰岛构成内分泌胰腺，调节血糖的动态平衡，它们的功能失调会导致糖尿病。每个胰岛构成一个完整的微器官，具有复杂的细胞间相互作用，并有良好的血管和神经。胰岛移植的一个重要的治疗优势是胰岛在分离和移植给严重糖尿病患者时保持其器官的完整性。一旦移植，胰岛微器官就会积极促进自身的血管形成，并立即开始发挥作用。因此，在器官移植方面，胰岛的应用将成为未来糖尿病治疗的决定性临床工具(来源：Tilo Moeed)。
The islets of Langerhans constitute the endocrine pancreas which regulates blood glucose homeostasis and their dysfunction results in diabetes. Each of the pancreatic islets constitutes an entire micro-organ with intricate cell to cell interactions and that is well vascularized and innervated. An important therapeutic advantage in islet transplant is that pancreatic islets maintain their organ integrity when isolated and transplanted to patients with severe diabetes. Once transplanted, the islet micro-organs actively contribute to their own vascularization and start to function immediately. Hence, in terms of organ transplantation, the application of pancreatic islets will be a decisive clinical tool for future diabetes care (credit: Tilo Moede).