Adverse Effects of Circadian Disorganization on Mood and Molecular Rhythms in the Prefrontal Cortex of Mice
Adverse Effects of Circadian Disorganization on Mood and Molecular Rhythms in the Prefrontal Cortex of Mice
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DOI：
10.1016/j.neuroscience.2020.02.013
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发表时间：
2020-04-15
期刊：
影响因子：
3.3
通讯作者：
Maeda, Masanobu
中科院分区：
文献类型：
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作者：
Otsuka, Tsuyoshi;Le, Hue Thi;Maeda, Masanobu
轮班工作和时差等情况导致睡眠和清醒的日常周期紊乱，可能会增加患上包括焦虑和抑郁在内的情感障碍的风险。然而，这种昼夜节律混乱是如何扰乱情绪调节的，目前还不是很清楚。更具体地说，昼夜节律紊乱对控制情绪的神经元功能的日常节律的影响尚不清楚。因此，我们研究了昼夜节律紊乱对大脑几个情绪控制区时钟基因和即刻早期基因(IEGs)表达节律的影响。为了引入行为的昼夜节律紊乱，我们将雄性C57BL/6J小鼠暴露于慢性反转的明暗周期中，我们发现这些小鼠有明显的负面情绪表型。重要的是，与大脑其他与情绪相关的区域相比，昼夜节律紊乱对Clock和IEGs表达节律的影响在前额皮质(PFC)观察到最不利的影响。因此，PFC中分子节律的失调被认为与包括倒班工作和时差在内的情绪障碍的发展有关。(C)2020 IBRO。爱思唯尔有限公司出版。保留所有权利。
Disturbance of the daily cycles in sleep and wakefulness induced by conditions such as shift work and jet lag can increase the risk of affective disorders including anxiety and depression. The way such circadian disorganization disrupts the regulation of mood, however, is not well understood. More specifically, the impact of circadian disorganization on the daily rhythms of the neuronal function that controls mood remains unclear. We therefore investigated the effects of circadian disorganization on expression rhythms of clock genes as well as immediate early genes (IEGs) in several mood-controlling regions of the brain. To introduce circadian disorganization of behaviors, we exposed male C57BL/6J mice to chronic reversal of the light-dark cycle and we found a marked negative mood phenotype in these mice. Importantly, the most adverse effect of circadian disorganization on expression rhythms of clock and IEGs was observed in the prefrontal cortex (PFC) when compared to that in other mood-related areas of the brain. Dysregulation of molecular rhythms in the PFC is therefore suggested to be associated with the development of mood disorders in conditions including shift work and jet lag. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.