The application of positron emission tomography to the study of panic disorder.
The application of positron emission tomography to the study of panic disorder.
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正电子发射断层扫描在惊恐障碍研究中的应用。
DOI：
10.1176/ajp.143.4.469
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Perlmutter,J
中科院分区：
文献类型：
--
作者：
Reiman,EM;Raichle,ME;Robins,E;Butler,FK;Herscovitch,P;Fox,P;Perlmutter,J
正电子发射断层扫描被用来研究8例惊恐障碍谁是容易受到乳酸盐引起的恐慌，8例惊恐障碍谁是不容易受到乳酸盐引起的恐慌，和25名正常对照组。易受乳酸盐诱导的恐慌的患者在静息状态下有几种异常：海马旁血流量、血容量和氧代谢的异常半球不对称;异常高的全脑代谢;以及对阵发性过度通气的异常易感性。一个假设的惊恐障碍的神经生物学模型，涉及异常的海马旁区及其传入和传出连接，提出。
Positron emission tomography was used to study eight patients with panic disorder who were vulnerable to lactate-induced panic, eight patients with panic disorder who were not vulnerable to lactate-induced panic, and 25 normal control subjects. Patients who were vulnerable to lactate-induced panic had several abnormalities in the resting, nonpanic state: an abnormal hemispheric asymmetry of parahippocampal blood flow, blood volume, and oxygen metabolism; abnormally high whole brain metabolism; and abnormal susceptibility to episodic hyperventilation. A hypothetical model for the neurobiology of panic disorder, involving the abnormal parahippocampal region and its afferent and efferent connections, is proposed.