PROTECTION OF SUCKLING MICE FROM EXPERIMENTAL CHOLERA BY MATERNAL IMMUNIZATION - COMPARISON OF EFFICACY OF WHOLE-CELL,RIBOSOMAL-DERIVED, AND ENTEROTOXIN IMMUNOGENS
PROTECTION OF SUCKLING MICE FROM EXPERIMENTAL CHOLERA BY MATERNAL IMMUNIZATION - COMPARISON OF EFFICACY OF WHOLE-CELL,RIBOSOMAL-DERIVED, AND ENTEROTOXIN IMMUNOGENS
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DOI：
10.1128/iai.10.1.167-172.1974
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发表时间：
1974-01-01
影响因子：
3.1
通讯作者：
BERRY, LJ
中科院分区：
文献类型：
--
作者：
GUENTZEL, MN;BERRY, LJ
The susceptibility of suckling mice to oral infection with several differentVibrio choleraewas determined. Mice up to 10 days of age were uniformly susceptible to oral infection with 108colony-forming units of virulent organisms. Age-dependent resistance occurred thereafter to a maximum at about 15 days of age. The efficacy of selected vaccines was compared by oral challenge of 8-day-old, passively immunized CFW mice. An Ogawa-derived ribosomal antigen was found to be superior to a commercial whole-cell vaccine or to purified cholera enterotoxin. The ribosomal antigen was 50- to 100-fold more protective than the other vaccines on a weight basis against otherwise lethal challenge with Ogawa, Inaba, or El Tor Ogawa serotypes.
