Significance of CD66c expression in childhood acute lymphoblastic leukemia
Significance of CD66c expression in childhood acute lymphoblastic leukemia
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DOI：
10.1016/j.leukres.2013.10.008
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发表时间：
2014-01-01
影响因子：
2.7
通讯作者：
Ohara, Akira
中科院分区：
文献类型：
--
作者：
Kiyokawa, Nobutaka;Iijima, Kazutoshi;Ohara, Akira
通过对695例儿童前体B细胞急性淋巴细胞白血病（BCP-ALL）的分析，明确了CD 36 c的表达特点。除了证实与BCR-ABL阳性和超二倍体的错误相关性外，我们还进一步观察到CD 66 c在CRLF 2阳性（11/15，p < 0.01）中频繁表达，与染色体基因阴性的细胞相比，作为超二倍体病例（314），而Sic在ETVA-RUNX 1、MLL-AF 4、MLL-AF 9、MLL-ENL和E2 A-PBX 1阳性病例中从不表达，虽然CD 66 c表达本身与预后无直接关系，但伴随的遗传异常是BCP-ALL的重要预后因素，表明CD 66 c表达在BCP-ALL的初步诊断中的重要性。(C)2013爱思唯尔有限公司版权所有。
Upon analyze in 695 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD36c expression. In addition to the confirmation of wrong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chiineric gene-negative foss ell as hypediploid cases (314 whereas Sic never expressed in ETVA-RUNX1 MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases, Although the expression CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BC P-ALL indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL. (C) 2013 Elsevier Ltd. All rights reserved.