Prognostic significance of diabetes mellitus in locally advanced non-small cell lung cancer.
Prognostic significance of diabetes mellitus in locally advanced non-small cell lung cancer.
复制标题
糖尿病在局部晚期非小细胞肺癌中的预后意义。
DOI：
10.1186/s12885-015-2012-4
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发表时间：
2015-12-21
期刊：
影响因子：
3.8
通讯作者：
Takahashi T
中科院分区：
文献类型：
--
作者：
Imai H;Kaira K;Mori K;Ono A;Akamatsu H;Matsumoto S;Taira T;Kenmotsu H;Harada H;Naito T;Murakami H;Endo M;Nakajima T;Yamada M;Takahashi T
探讨局部晚期非小细胞肺癌（NSCLC）患者特征和临床实验室检测结果的预后意义，特别是糖尿病（DM）对接受放化疗患者生存的影响。我们回顾性审查了 159 名局部晚期 NSCLC 患者，重点关注 DM 和其他潜在预后因素，使用对数秩检验以及单变量和多变量分析来评估其与生存的相关性。单变量分析确定了五个显着的预后因素：分期（p<0.001）、DM（p=0.04）、血红蛋白水平（p=0.003）、血清白蛋白（p<0.001）和乳酸脱氢酶（LDH）水平（p=0.01）。此外，在使用Fisher精确检验和Wilcoxon秩和检验检验的因素中，发现性别（p = 0.019）和血浆葡萄糖水平（p<0.001）具有预后意义。多变量分析显示分期、DM、血清白蛋白和LDH水平是生存的独立预后因素（分别为p = 0.007、p = 0.024、p = 0.007和p = 0.005）。诊断时存在 DM 被认为是预测局部晚期 NSCLC 患者阴性结果的独立且重要的预后因素。
To investigate the prognostic significance of patient characteristics and clinical laboratory test results in locally advanced non-small cell lung cancer (NSCLC), and in particular the impact of diabetes mellitus (DM) on the survival of patients who underwent chemoradiotherapy. We retrospectively reviewed 159 patients with locally advanced NSCLC with a focus on DM and other potential prognostic factors, using the log-rank test, and univariate and multivariate analyses to assess their association with survival. Five significant prognostic factors were identified in univariate analysis: stage (p < 0.001), DM (p = 0.04), hemoglobin levels (p = 0.003), serum albumin (p <0.001) and lactate dehydrogenase (LDH) levels (p = 0.01). Furthermore, among the factors tested using Fisher's exact test and the Wilcoxon rank sum test, gender (p = 0.019) and plasma glucose level (p <0.001) were found to have prognostic significance. Multivariate analysis showed that stage, DM, serum albumin and LDH levels were independent prognostic factors for survival (p = 0.007, p = 0.024, p = 0.007 and p = 0.005, respectively). The presence of DM at the time of diagnosis was identified as an independent and significant prognostic factor for predicting negative outcome in locally advanced NSCLC patients.