Neurotrophic factors in the auditory periphery
Neurotrophic factors in the auditory periphery
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DOI：
10.1111/j.1749-6632.1999.tb08649.x
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Ylikoski, J
中科院分区：
文献类型：
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作者：
Qun, LX;Pirvola, U;Ylikoski, J
许多神经营养因子促进发育中的外周感觉神经元的存活，并且它们可能在成人神经系统中用作治疗剂。在发育过程中，神经营养因子-3（NT-3）和脑源性神经营养因子（BDNF）mRNA在听觉感觉上皮中表达，听觉感觉上皮构成耳蜗（螺旋）神经元的外周靶区。NT-3 mRNA也在成熟Corti器的内毛细胞中表达。编码其信号转导受体TrkC和TrkB的mRNA分别在耳蜗神经元中表达。除了神经营养因子，这似乎有一个重要的作用，在发展过程中，另一种神经营养因子，胶质细胞源性神经营养因子（GDNF），似乎参与了出生后的听觉神经元的维护。在本工作中，神经营养素和GDNF在发育和成年大鼠内耳的细胞分布进行了比较。并比较了重组神经营养素和GDNF对离体耳蜗神经元的作用。最近，NT-3和BDNF被用作体内治疗剂，以保护豚鼠耳蜗神经元免受氨基糖苷类诱导的变性和GDNF免受噪声诱导的变性。这些数据表明，NT-3，BDNF和GDNF可能是预防人类听神经变性的潜在候选者。
Many of the neurotrophic factors promote the survival of developing peripheral sensory neurons, and they might be useful as therapeutic agents in the adult neuronal systems. During development, neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) mRNAs are expressed in the auditory sensory epithelium, which composes the peripheral target field of the cochlear (spiral) neurons. NT-3 mRNA is also expressed in the inner hair cells of the mature organ of Corti. mRNAs encoding their signal-transducing receptors, TrkC and TrkB, respectively, are expressed in the cochlear neurons. In addition to neurotrophins, which seem to have an important role during development, another neurotrophic factor, glial cell-line-derived neurotrophic factor (GDNF), seems to be involved in the maintenance of postnatal auditory neurons. In the present work, the cellular distribution of neurotrophins and GDNF in the developing and adult rat inner ear are compared. The effects of recombinant neurotrophins and GDNF on dissociated cochlear neurons in vitro are also compared. Recently, NT-3 and BDNF were used in vivo as therapeutic agents to protect guinea pig cochlear neurons from aminoglycoside-induced degeneration and GDNF from noise-induced degeneration. These data demonstrate that NT-3, BDNF, and GDNF might be potential candidates for prevention of degeneration of the auditory nerve in man.