Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study.
Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study.
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DOI：
10.1097/01.gme.0000109314.11228.e5
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发表时间：
2004-07-01
影响因子：
2.7
通讯作者：
Squadrito, F
中科院分区：
文献类型：
--
作者：
Crisafulli, A;Marini, H;Squadrito, F
目的：我们评估并比较了植物雌激素染料木黄酮、雌激素-孕激素治疗（EPT）和安慰剂对绝经后妇女潮热和子宫内膜厚度的影响。设计：90名健康的绝经后妇女，年龄47至57岁，被随机分配接受为期一年的连续EPT（n = 30; 1 mg 17 β-雌二醇与0.5mg醋酸炔诺酮组合）、植物雌激素染料木黄酮（n = 30; 54 mg/天）或安慰剂（n = 30）。在基线、6个月和12个月时通过阴道超声评价子宫内膜安全性。结果：与安慰剂相比，每日潮红平均减少22%（95%CI：-38至-6.2; P < 0.01）3个月后，平均29%（95%CI：-45至-13; P < 0.001），并且在染料木黄酮治疗12个月后平均降低24%（95%CI：-43至-5; P < 0.01）。潮红评分平均下降53%（95% CI：-79至-26; P < 0.001）3个月后，平均56%与安慰剂相比，EPT治疗6个月后平均降低54%（95% CI：-83至-28; P < 0.001），12个月后平均降低54%（95% CI：-74至-33; P < 0.001）。没有观察到副作用对子宫的participants.Conclusions：本研究证实，金雀异黄素可能有积极的影响，潮热没有对子宫内膜厚度的负面影响，并提出了未来的作用，这种植物雌激素作为一种战略性的治疗选择，在管理绝经后症状。
Objective: We evaluated and compared the effects of the phytoestrogen genistein, estrogen-progestogen therapy (EPT), and placebo on hot flushes and endometrial thickness in postmenopausal women.Design: Ninety healthy, postmenopausal women, 47 to 57 years of age, were randomly assigned to receive for I year continuous EPT (n = 30; 1 mg 17beta-estradiol combined with 0.5 mg norethisterone acetate), the phytoestrogen genistein (n = 30; 54 mg/day), or placebo (n = 30). Endometrial safety was evaluated by intravaginal ultrasounds at baseline, 6 and 12 months.Results: By comparison with placebo, daily flushes reduced significantly by a mean of 22% (95% CI: -38 to -6.2; P < 0.01) after 3 months, by a mean of 29% (95% CI: -45 to -13; P < 0.001) after 6 months, and by a mean of 24% (95% CI: -43 to -5; P < 0.01) after 12 months of genistein treatment. Flush score decreased by a mean of 53% (95% CI: -79 to -26; P < 0.001) after 3 months, by a mean of 56% (95% CI: -83 to -28; P < 0.001) after 6 months, and by a mean of 54% (95% CI: -74 to -33; P < 0.001) after 12 months of EPT, as compared with placebo. No side effect was observed on the uterus of the participants.Conclusions: The present study confirms that genistein might have positive effects on hot flushes without a negative impact on endometrial thickness and suggests a future role of this phytoestrogen as a strategically therapeutic alternative in the management of postmenopausal symptoms.