Body size-dependent energy storage causes Kleiber’s law scaling of the metabolic rate in planarians
Body size-dependent energy storage causes Kleiber’s law scaling of the metabolic rate in planarians
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DOI：
10.1101/332916
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发表时间：
2018-05
期刊：
影响因子：
7.7
通讯作者：
J. Rink;A. Thommen;Steffen Werner;Olga Frank;J. Philipp;Oskar Knittelfelder;Yihui Quek;K. Fahmy;A. Shevchenko;B. Friedrich;F. Jülicher
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文献类型：
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作者：
J. Rink;A. Thommen;Steffen Werner;Olga Frank;J. Philipp;Oskar Knittelfelder;Yihui Quek;K. Fahmy;A. Shevchenko;B. Friedrich;F. Jülicher
克莱伯定律，或者说代谢率与体重的 3/4 幂定律，被认为是生物学中为数不多的定量定律之一，但其生理学基础仍然未知。在这里，我们报告了涡虫 Schmidtea mediterranea 中的克莱伯缩放定律。成人身体大小超过两个数量级的可逆且与生活史无关的变化表明，克莱伯定律并不是来自细胞代谢率的大小依赖性下降，而是来自每个细胞质量的大小依赖性增加。通过对生物体能量平衡的实验和理论分析相结合，我们进一步表明质量异速是由身体尺寸依赖性能量储存引起的。我们的结果揭示了涡虫中克莱伯定律的生理起源，因此对于理解生物学中的基本缩放定律具有一般意义。
Kleiber’s law, or the ¾-power law scaling of the metabolic rate with body mass, is considered one of the few quantitative laws in biology, yet its physiological basis remains unknown. Here, we report Kleiber’s law scaling in the planarian Schmidtea mediterranea. Its reversible and life history-independent changes in adult body size over 2 orders of magnitude reveal that Kleiber’s law does not emerge from the size-dependent decrease in cellular metabolic rate, but from a size-dependent increase in mass per cell. Through a combination of experiment and theoretical analysis of the organismal energy balance, we further show that the mass allometry is caused by body size dependent energy storage. Our results reveal the physiological origins of Kleiber’s law in planarians and thus have general implications for understanding a fundamental scaling law in biology.