Association of LAPTM4B gene polymorphism with nasopharyngeal carcinoma susceptibility in a Chinese population
Association of LAPTM4B gene polymorphism with nasopharyngeal carcinoma susceptibility in a Chinese population
复制标题
DOI：
10.1007/s12032-013-0470-6
复制
发表时间：
2013-03-01
期刊：
影响因子：
3.4
通讯作者：
Zhang, Qingyun
中科院分区：
文献类型：
--
作者：
Wang, Bing;Xu, Jianjun;Zhang, Qingyun
溶酶体相关蛋白跨膜4 β（LAPTM 4 B）是一个新的肿瘤相关基因。它有两个等位基因命名为LAPTM 4 B *1和LAPTM 4 B *2。先前的研究表明，LAPTM 4 B多态性与许多癌症的风险有关。本研究的目的是探讨不同LAPTM 4 B等位基因与中国南方最常见的癌症之一鼻咽癌（NPC）的风险之间的关联。采用聚合酶链反应（PCR）方法，对134例鼻咽癌患者和327例正常人外周血进行LAPTM 4 B基因型检测。分类变量差异分析采用卡方检验，Hardy-Weinberg平衡分析采用卡方检验。采用非条件logistic回归模型计算比值比和95%CI。鼻咽癌组等位基因 *2频率为26.87%，与对照组（27.98%，P = 0.867）比较差异无统计学意义。以LAPTM 4 B *1/1基因型为参照，我们发现 *1/2、*2/2和 *1/2 + *2/2基因型也与鼻咽癌的危险性无关。LAPTM 4 B基因多态性与经性别和年龄校正的鼻咽癌风险之间未观察到关联。本研究结果提示LAPTM 4 B基因多态性与中国人群鼻咽癌的易感性无关。需要大规模的研究来证实我们的发现。
Lysosome-associated protein transmembrane-4 beta (LAPTM4B) is a novel cancer-related gene. It has two alleles designated LAPTM4B*1 and LAPTM4B*2. Previous studies have revealed that LAPTM4B polymorphisms contribute to the risk of many cancers. The aim of this study was to investigate the association between different LAPTM4B alleles and the risk of nasopharyngeal carcinoma (NPC), one of the most common cancers in southern China. Using polymerase chain reaction (PCR) in a case-control study, we detected the LAPTM4B genotype in peripheral blood samples from 134 patients with NPC and 327 control subjects. The chi-square test was used to analyze differences of categorical variables and Hardy-Weinberg equilibrium. Odds ratios and 95 % CI were computed using an unconditional logistic regression model. The frequency of allele *2 was 26.87 % in the NPC group, which was not significantly different from that of the control group (27.98 %, P = 0.867). Using the LAPTM4B*1/1 genotype as a reference, we found that the *1/2, *2/2 and *1/2 + *2/2 genotype were also not associated with the risk of NPC. No association was observed between LAPTM4B gene polymorphisms and the risk of NPC adjusted by gender and age. The results of our study indicated that the polymorphism of LAPTM4B gene did not influence the susceptibility of NPC in the Chinese population. Large-scale studies are needed to confirm our findings.