Dexamethasone-containing biodegradable superparamagnetic microparticles for intra-articular administration: Physicochemical and magnetic properties, in vitro and in vivo drug release
Dexamethasone-containing biodegradable superparamagnetic microparticles for intra-articular administration: Physicochemical and magnetic properties, in vitro and in vivo drug release
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DOI：
10.1016/j.ejpb.2009.03.003
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发表时间：
2009-08-01
影响因子：
4.9
通讯作者：
Doelker, Eric
中科院分区：
文献类型：
--
作者：
Butoescu, Nicoleta;Jordan, Olivier;Doelker, Eric
与传统的药物溶液或悬浮液相比，聚合物微粒代表了实现受控和延长的药物递送到关节中的有价值的手段，但仍然存在在关节腔中的保留时间有限的缺点。在这项研究中，我们的目的是制备和表征磁性可生物降解的微粒含有醋酸地塞米松（DXM）批次关节内给药。由超顺磁性氧化铁纳米颗粒（SPION）的包封产生的超顺磁性允许微粒保留在空气外部磁场中，从而可能减少它们从关节中的清除。使用两种分子量的聚（乳酸-共-乙醇酸）（PLGA），12和19 kDa。制备的批次在尺寸（约10 μ m）、内部形态、表面形态、电荷（中性）和超顺磁性行为方面相似。通过TEM评估的微粒中的SPION分布表明均匀分布和不存在聚集，这是保持超顺磁性的重要因素。DXM释放曲线显示在体外非常相似（约。6天）和体内，使用小鼠背部气囊模型（约. 5天）。(C)2009 Elsevier B. V.保留所有权利。
Compared with traditional drug Solutions or suspensions, polymeric microparticles represent a Valuable means to achieve controlled and prolonged drug delivery into joints, but still suffer from the drawback of limited retention duration in the articular cavity. In this Study, Our aim was to prepare and characterize magnetic biodegradable microparticles containing dexamethasone acetate (DXM) lot intra-articular administration. The superparamagnetic Properties, which result from the encapsulation of superparamagnetic iron oxide nanoparticles (SPIONs), allow for microparticle retention with air external magnetic field, thus possibly reducing their clearance from the joint. Two molecular weights of poly(lactic-co-glycolic acid) (PLGA) were used, 12 and 19 kDa. The prepared batches were similar in size (around 10 pm), inner morphology surface morphology, charge (neutral) and superparamagnetic behaviour. The SPION, distribution in the microparticles assessed by TEM indicates a homogeneous distribution and the absence of aggregation, an important factor for preserving superparamagnetic properties. DXM release Profiles were shown to be quite similar in vitro (ca. 6 days) and in Vivo, using a mouse dorsal air pouch model (ca. 5 days). (C) 2009 Elsevier B.V. All rights reserved.