The ACTN3 gene in elite Greek track and field athletes
The ACTN3 gene in elite Greek track and field athletes
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DOI：
10.1055/s-2007-965339
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发表时间：
2008-04-01
影响因子：
2.5
通讯作者：
Triantaphyllidis, C.
中科院分区：
文献类型：
--
作者：
Papadimitriou, I. D.;Papadopoulos, C.;Triantaphyllidis, C.
基因对奥运冠军产生影响的研究仍处于起步阶段，但最近的工作已经提供了有关ACTN3基因与运动成绩之间关系的发现。本研究的目的是通过分析ACTN3基因外显子15的单核苷酸多态性来研究希腊优秀田径运动员之间的遗传差异。结果显示，顶尖力量型运动员的ACTN3基因型和等位基因频率与希腊人群的代表性随机样本有统计学差异：力量型运动员的RR ACTN3基因型与一般人群的频率分别为47.94%和25.97%。这一结果在短跑运动员亚组与对照组的比较中更为突出。结果表明，RR基因型的存在与精英力量表现之间存在总体上很强的关联。
The study of genetic influence in the making of an Olympic champion is still in its nascence, but recent work has Provided findings regarding the association of the ACTN3 gene on athletic performance. The aim of this study was to examine genetic differences among elite Greek track and field athletes by anallysing a mononucleotide polymorphism in exon 15 of the ACTN3 gene. Results showed that ACTN3 genotype and allele frequencies in the top power-oriented athletes were statistically significantly different from those in a representative random sample of the Greek population: the frequency of the RR ACTN3 genotype in power-oriented athletes vs. the general population was 47.94% vs. 25.97%. This result was even more prominent for comparison of the subgroup of sprinters to controls. The results suggest an overall strong association between the presence of the RR genotype and elite power performance.