Optimization of Noninvasive Activation Studies with 15O-Water and Three-Dimensional Positron Emission Tomography
Optimization of Noninvasive Activation Studies with 15O-Water and Three-Dimensional Positron Emission Tomography
复制标题
15O-水和三维正电子发射断层扫描无创激活研究的优化
DOI：
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发表时间：
1997
影响因子：
6.3
通讯作者：
P. Herscovitch
中科院分区：
文献类型：
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作者：
N. Sadato;R. Carson;M. Daube;G. Campbell;M. Hallett;P. Herscovitch
我们研究了不同注射剂量、注射速度和扫描时间的影响，以最大限度地提高15O-水和三维正电子发射断层扫描的无创激活研究的灵敏度。在四名受试者中使用了一项隐蔽的单词生成任务，注射剂量为2.5到30毫升的15O-水。全脑的噪声当量计数(NEC)在注射剂量为12~15mCI时达到峰值。这比模体研究的预期要低，可能是因为大脑外的放射性影响。注射10mCI时，NEC为峰值的92.4±2.2%。当扫描持续时间从60秒增加到90秒到120秒时，激活区域的大小减小或不再被检测到。因此，我们选择了使用10MCI进行1分钟的团注扫描。然后，我们进行了模拟研究，以评估对于给定的脑血流变化，较长的扫描持续时间和缓慢的示踪剂注入对信噪比(S/N)的影响。使用来自团注注射的测量的动脉输入函数，对更长持续时间的注射的新输入函数和相应的组织数据进行模拟。结合来自霍夫曼脑模研究的图像噪声信息和模拟组织数据，可以计算给定脑血流变化的S/N。模拟表明，缓慢输注允许较长的扫描采集，而S/N的损失很小，这使得研究者可以选择注射持续时间，从而选择扫描值对局部CBF敏感的时间段。
We investigated the effects of varying the injected dose, speed of injection, and scan duration to maximize the sensitivity of noninvasive activation studies with 15O-water and three-dimensional positron emission tomography. A covert word generation task was used in four subjects with bolus injections of 2.5 to 30 mCi of 15O-water. The noise equivalent counts (NEC) for the whole brain peaked at an injected dose of 12 to 15 mCi. This was lower than expected from phantom studies, presumably because of the effect of radioactivity outside of the brain. A 10 mCi injection gave an NEC of 92.4 ± 2.2% of the peak value. As the scan duration increased from 60 to 90 to 120 seconds, the areas of activation decreased in size or were no longer detected. Therefore, we selected a 1 minute scan using 10 mCi for bolus injections. We then performed simulation studies to evaluate, for a given CBF change, the effect on signal-to-noise ratio (S/N) of longer scan duration with slow tracer infusions. Using a measured arterial input function from a bolus injection, new input functions for longer duration injections and the corresponding tissue data were simulated. Combining information about image noise derived from Hoffman brain phantom studies with the simulated tissue data allowed calculation of the S/N for a given CBF change. The simulation shows that a slow infusion permits longer scan acquisitions with only a small loss in S/N. This allows the investigator to choose the injection duration, and thus the time period during which scan values are sensitive to regional CBF.
使用切换范例改进 PET 激活研究中的信噪比。
DOI：
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发表时间：
1995
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Cherry,SR;Woods,RP;Doshi,NK;Banerjee,PK;Mazziotta,JC
通讯作者：
Mazziotta,JC