Potential of stem-cell-based therapies for heart disease
Potential of stem-cell-based therapies for heart disease
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DOI：
10.1038/nature04961
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发表时间：
2006-06-28
期刊：
影响因子：
64.8
通讯作者：
Ivey, KN
中科院分区：
文献类型：
--
作者：
Srivastava, D;Ivey, KN
利用干细胞为受损的心肌、心脏瓣膜、血管和传导细胞生成替代细胞具有巨大潜力。近期在心脏中发现了多能祖细胞，并且对与多能胚胎干细胞相关的发育过程有了更深入的了解，这可能有助于生成可用于治疗人类心脏病的特定类型的细胞。循环祖细胞分泌的因子可定位到损伤部位，这些因子可能也有助于组织保护或新血管形成。基础科学领域的这些令人兴奋的发现需要在动物模型中进行严格测试，以确定最值得进行未来临床试验的方法。
The use of stem cells to generate replacement cells for damaged heart muscle, valves, vessels and conduction cells holds great potential. Recent identification of multipotent progenitor cells in the heart and improved understanding of developmental processes relevant to pluripotent embryonic stem cells may facilitate the generation of specific types of cell that can be used to treat human heart disease. Secreted factors from circulating progenitor cells that localize to sites of damage may also be useful for tissue protection or neovascularization. The exciting discoveries in basic science will require rigorous testing in animal models to determine those most worthy of future clinical trials.