Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke
Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke
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DOI：
10.1161/strokeaha.120.029123
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发表时间：
2020-08-01
期刊：
影响因子：
8.3
通讯作者：
Fornage, Myriam
中科院分区：
文献类型：
--
作者：
Keene, Keith L.;Hyacinth, Hyacinth I.;Fornage, Myriam
背景和目的：脑卒中是一种复杂的疾病，有多种遗传和环境危险因素。黑人患中风的风险几乎是欧洲裔美国人的2倍，死于中风的可能性是欧洲裔美国人的2倍至3倍。研究方法：COMPASS（少数民族人群全基因组卒中关联研究联盟）对来自13个队列的> 22000名非洲血统个体（3734例病例，18317例对照）进行了全基因组卒中关联荟萃分析。结果如下：在荟萃分析中，我们确定了一个接近HNF 1A基因的单核苷酸多态性（rs 55931441），达到了全基因组显著性（P=4.62x10（-8）），另外29个变异体具有提示性关联证据（P
Background and Purpose: Stroke is a complex disease with multiple genetic and environmental risk factors. Blacks endure a nearly 2-fold greater risk of stroke and are 2x to 3x more likely to die from stroke than European Americans. Methods: The COMPASS (Consortium of Minority Population Genome-Wide Association Studies of Stroke) has conducted a genome-wide association meta-analysis of stroke in >22 000 individuals of African ancestry (3734 cases, 18 317 controls) from 13 cohorts. Results: In meta-analyses, we identified one single nucleotide polymorphism (rs55931441) near theHNF1Agene that reached genome-wide significance (P=4.62x10(-8)) and an additional 29 variants with suggestive evidence of association (P