Degradable poly(anhydride ester) implants: effects of localized salicylic acid release on bone
Degradable poly(anhydride ester) implants: effects of localized salicylic acid release on bone
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DOI：
10.1016/s0142-9612(00)00118-6
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发表时间：
2000-12-01
期刊：
影响因子：
14
通讯作者：
Uhrich, KE
中科院分区：
文献类型：
--
作者：
Erdmann, L;Macedo, B;Uhrich, KE
研究了聚合物骨架分解为水杨酸（SA）的可降解聚酸酐酯植入物。在这项初步工作中，我们利用小鼠模型评估了聚酸酐酯（被归类为“活性聚合物”）在健康骨骼和组织中的局部释放。分解成无活性副产物的可降解聚酸酐被用作控制膜，因为它们的化学性质与活性聚合物相似。在靠近上颌第一磨牙的暴露腭骨上插入小聚合物方块。活性聚合物膜放置在口腔一侧，对照聚合物放置在对侧。口腔内临床检查显示活性聚合物部位比对照聚合物部位肿胀和炎症减轻。第1天的组织病理学检查显示，对照组和活性聚合物之间基本上没有差异。4天后，活性聚合物部位的上皮增生程度高于聚酸酐对照组。20天后，活性聚合物部位的新腭骨厚度增加，无骨吸收区，而对照聚合物部位骨厚度减少，骨吸收包括牙骨质和牙本质的陷窝。从这些初步研究中，我们得出结论，活性聚合物，即聚酸酐酯，刺激新骨的形成。(C) 2000 Elsevier Science Ltd.版权所有。
Degradable poly(anhydride ester) implants in which the polymer backbone breaks down into salicylic acid (SA) were investigated. In this preliminary work, local release of SA from the poly(anhydride esters), thus classified as 'active polymers', on healthy bone and tissue was evaluated in vivo using a mouse model. Degradable polyanhydrides that break down into inactive by-products were used as control membranes because of their chemical similarity to the active polymers. Small polymer squares were inserted over the exposed palatal bone adjacent to the maxillary first molars. Active polymer membranes were placed on one side of the mouth, control polymers placed on the contralateral side. Intraoral clinical examination showed that active polymer sites were less swollen and inflamed than control polymer sites. Histopathological examination at day 1 showed essentially no difference between control and active polymers. After 4 days, active polymer sites showed epithelial proliferation to a greater extent than the polyanhydride controls. After 20 days, active polymer sites showed greater thickness of new palatal bone and no resorptive areas, while control polymer sites showed less bone thickness as well as resorption including lacunae involving cementum and dentine. From these preliminary studies, we conclude that active polymers, namely poly(anhydride esters), stimulated new bone formation. (C) 2000 Elsevier Science Ltd. All rights reserved.