Interactive SARS-CoV-2 mutation timemaps.
Interactive SARS-CoV-2 mutation timemaps.
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DOI：
10.12688/f1000research.50857.2
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Birol I
中科院分区：
文献类型：
--
作者：
Warren RL;Birol I
随着2020年接近尾声，报告了几种新的严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）菌株，这是导致2019冠状病毒病（COVID-19）大流行的病原体，过去一年一直困扰着我们。然而，很难理解SARS-CoV-2在其人类宿主中变异和进化的序列空间、地理位置和时间的规模。为了了解冠状病毒的快速进化，我们构建了交互式可扩展矢量图形地图，显示了来自六个人口最多的大陆的基因组中的每日核苷酸变异，与大流行开始时测序的最初的零地SARS-CoV-2分离株相比。 可用性：用于执行报告的突变分析结果的工具ntEdit可从GitHub获得。基因组突变报告可从BCGSC下载。突变时间图可从https://bcgsc.github.io/SARS2/获得。
As the year 2020 came to a close, several new strains have been reported of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the coronavirus disease 2019 (COVID-19) pandemic that has afflicted us all this past year. However, it is difficult to comprehend the scale, in sequence space, geographical location and time, at which SARS-CoV-2 mutates and evolves in its human hosts. To get an appreciation for the rapid evolution of the coronavirus, we built interactive scalable vector graphics maps that show daily nucleotide variations in genomes from the six most populated continents compared to that of the initial, ground-zero SARS-CoV-2 isolate sequenced at the beginning of the pandemic. Availability: The tool used to perform the reported mutation analysis results, ntEdit, is available from GitHub. Genome mutation reports are available for download from BCGSC. Mutation time maps are available from https://bcgsc.github.io/SARS2/.