GLP-1 and GLP-2 act in concert to inhibit fasted, but not fed, small bowel motility in the rat
GLP-1 and GLP-2 act in concert to inhibit fasted, but not fed, small bowel motility in the rat
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DOI：
10.1016/s0167-0115(02)00095-2
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发表时间：
2002-07-15
影响因子：
--
通讯作者：
Hellström, PM
中科院分区：
文献类型：
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作者：
Bozkurt, A;Näslund, E;Hellström, PM
大鼠静脉注射高血糖素样多肽-1(GLP-1)或高血糖素样多肽-2(GLP-2)，或联合应用GLP-1或GLP-2，在禁食和喂食状态下，观察大鼠静脉注射GLP-1或GLP-2剂量增加(1~20pmol/kg/min)时的小肠运动。GLP-1对移行性肌电复合体(MMC)的抑制作用呈剂量依赖性，其中5pmol/kg/min剂量引起MMC周期延长。GLP-2单独作用不明显，但GLP-1和GLP-2联合应用时抑制作用更明显，从2pmol/kg/min开始，MMC周期明显延长。在摄食运动过程中，与对照相比，注射GLP-1可抑制刺激性活动。相反，与对照相比，注射GLP-2仅在数值上增加了刺激性活动，而GLP-1和GLP-2的组合与对照相比没有引起任何变化。综上所述，本研究证实了外周应用GLP-1和GLP-2对空腹小肠运动的相加作用。在进食状态下，GLP-1和GLP-2似乎对小肠的运动具有平衡作用。(C)2002 Elsevier Science B.V.保留所有权利。
Small bowel motility was studied in rats at increasing (1-20 pmol/kg/min) intravenous doses of either glucagon-like peptide-1 (GLP-1) or glucagon-like peptide-2 (GLP-2) alone, or in combination in the fasted and fed state. There was a dose-dependent inhibitory action of GLP-1 on the migrating myoelectric complex (MMC), where the dose of 5 pmol/kg/min induced an increased MMC cycle length. No effect was seen with GLP-2 alone, but the combination of GLP-1 and GLP-2 induced a more pronounced inhibitory effect, with significant increase of the MMC cycle length from a dose of 2 pmol/kg/min. During fed motility, infusion of GLP-1 resulted in an inhibition of spiking activity compared to control. In contrast, infusion of GLP-2 only numerically increased spiking activity compared to control, while the combination of GLP-1 and GLP-2 resulted in no change compared to control. In summary, this study demonstrates an additive effect of peripheral administration of GLP-1 and GLP-2 on fasted small bowel motility. In the fed state, GLP-1 and GLP-2 seem to display counter-balancing effects on motility of the small intestine. (C) 2002 Elsevier Science B.V All rights reserved.