An Efficient Subset of Morphological Measures for Articular Cartilage in the Healthy and Diseased Human Knee
An Efficient Subset of Morphological Measures for Articular Cartilage in the Healthy and Diseased Human Knee
复制标题
DOI：
10.1002/mrm.22207
复制
发表时间：
2010-03-01
影响因子：
3.3
通讯作者：
Eckstein, Felix
中科院分区：
文献类型：
--
作者：
Buck, Robert J.;Wyman, Bradley T.;Eckstein, Felix
检查膝关节软骨通常采用的基于MRI的三维形态学测量之间的关系，以确定变量子集是否完全反映了在横截面和纵向研究中观察到的软骨差异。测量子集的益处包括由于减少多重比较而增加的统计功效、改善对关节膝软骨的形态测量之间的关系的理解以及更高的报告结果效率。152名女性（77名健康女性和75名膝关节骨关节炎患者）在基线和24个月时获得了膝关节的冠状面3-T MR图像。测量股胫软骨形态（表面积、厚度、体积等）在内侧和外侧胫骨和股骨中测定。发现软骨厚度（[软骨下]骨总面积上的平均软骨厚度）、软骨下骨总面积和软骨下骨裸露面积的百分比可以解释膝关节骨关节炎中常见的软骨形态学其他测量中观察到的90%以上的横截面和纵向变化。因此，这三种软骨形态测量方法几乎解释了健康和骨关节炎膝关节中横截面和纵向上更大一组常见软骨形态测量方法的所有变化。因此，这些变量定义了一个有效的子集，用于描述骨关节炎软骨的结构状态和变化。Magn Reson Mad 63：680-690，2010. (C)2010 Wiley-Liss，Inc.
The relationship between three-dimensional, MRI-based morphologic measurements commonly taken of knee cartilage was examined to determine whether a subset of variables fully reflects differences observed in cartilage in cross-sectional and longitudinal studies. The benefits of a subset of measures include increased statistical power due to reduced multiple comparisons, improved understanding of relationships between the morphologic measures of articular knee cartilage, and greater efficiency in reporting results. One hundred fifty-two women (77 healthy and 75 with knee osteoarthritis) had coronal 3-T MR images of the knee acquired at baseline and at 24 months. Measures of femorotibial cartilage morphology (surface area, thickness, volume, etc.) were determined in the medial and lateral tibia and femur. Cartilage thickness (mean cartilage thickness over the total area of the [subchondral] bone), total subchondral bone area, and percentage of denuded area of the subchondral bone were found to explain over 90% of the cross-sectional and longitudinal variation observed in other measures of cartilage morphology commonly reported in knee osteoarthritis. Hence, these three measures of cartilage morphology explain nearly all variation in a larger set of common cartilage morphology measures both cross-sectionally and longitudinally, both in healthy and in osteoarthritic knees. These variables hence define an efficient subset for describing structural status and change in osteoarthritic cartilage. Magn Reson Mad 63:680-690, 2010. (C) 2010 Wiley-Liss, Inc.