Geographic Heterogeneity of Prevalence of the Human Herpesvirus 8 in Sub-Saharan Africa: Clues About Etiology
Geographic Heterogeneity of Prevalence of the Human Herpesvirus 8 in Sub-Saharan Africa: Clues About Etiology
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DOI：
10.1016/j.annepidem.2010.07.098
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发表时间：
2010-12-01
影响因子：
5.6
通讯作者：
Mbulaiteye, Sam M.
中科院分区：
文献类型：
--
作者：
Pfeiffer, Ruth M.;Wheeler, William A.;Mbulaiteye, Sam M.
目得：人类疱疹病毒8（HHV-8，或卡波西肉瘤[KS]相关疱疹病毒，KSHV）是KS的必要但不充分的原因，因为KS在少数HHV-8感染者中发展。在撒哈拉以南非洲，HHV-8和KS的地理分布存在显著差异，表明环境辅助因素影响HHV-8的传播、控制和进展为KS。然而，直接比较HHV-8流行率估计是复杂的，因为研究使用不同的血清学检测和分析方法。我们评估了HHV-8血清阳性在几个非洲国家的异质性环境和不同的KS发病率使用统一的approach.METHODS：HHV-8抗体测定3196成人（年龄20岁以上）和2404名儿童（年龄< 20岁）从5项研究在非洲撒哈拉以南非洲国家。血清样本进行测试，由同一实验室使用K8.1和orf 73酶immunoassays.RESULTS：儿童的HHV-8血清阳性率范围从18.1%的坎帕拉，乌干达，到33.8%的北马拉，坦桑尼亚，在所有人群中，随着年龄的增长急剧增加。在成人中，HHV-8血清阳性率从尼日利亚的23.5%到乌干达西尼罗河农村的70.6%不等。这是较高的男性和农村areas.CONCLUSIONS：我们的数据表明，地理暴露，性别，年龄和相关因素与农村居住的影响HHV-8血清阳性在撒哈拉以南非洲。Ann Epidemiol 2010;20：958-963. (C)2010年爱思唯尔公司All rights reserved.
PURPOSE: Human herpesvirus 8 (HHV-8, or Kaposi sarcoma [KS]-associated herpesvirus, KSHV) is a necessary but insufficient cause of KS, as KS develops in few HHV-8-infected persons. In sub-Saharan Africa, marked differences in the geographic distribution of HHV-8 and KS suggest that environmental cofactors influence HHV-8 transmission, control, and progression to KS. However, a direct comparison of HHV-8 prevalence estimates is complicated because studies used different serologic assays and analytic methods. We assessed HHV-8 seropositivity in several African countries with heterogeneous environments and varying KS incidence using a unified approach.METHODS: HHV-8 antibodies were measured among 3196 adults (aged 20+ years) and 2404 children (aged < 20 years) from five studies in four sub-Saharan countries in Africa. Serum samples were tested by the same laboratory using K8.1 and orf73 enzyme immunoassays.RESULTS: Children's HHV-8-seropositivity ranged from 18.1% in Kampala, Uganda, to 33.8% in North Mara, Tanzania, increasing steeply with age in all populations. Among adults, HHV-8-seropositivity ranged from 23.5% in Nigeria to 70.6% in rural West Nile, Uganda. It was higher in males and rural areas.CONCLUSIONS: Our data indicate that geographical exposures, gender, age, and factors correlated with rural residence impact HHV-8 seropositivity in sub-Saharan Africa. Ann Epidemiol 2010;20:958-963. (C) 2010 Elsevier Inc. All rights reserved.