Lactoferrin: A multifunctional glycoprotein involved in the modulation of the inflammatory process
Lactoferrin: A multifunctional glycoprotein involved in the modulation of the inflammatory process
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DOI：
10.1515/cclm.1999.049
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发表时间：
1999-03-01
影响因子：
6.8
通讯作者：
Legrand, D
中科院分区：
文献类型：
--
作者：
Baveye, S;Elass, E;Legrand, D
乳铁蛋白是一种存在于哺乳动物外分泌物中的铁结合糖蛋白，在炎症过程中由嗜酸性颗粒释放。本文综述了乳铁蛋白在宿主防御中的生物学作用。分泌的乳铁蛋白通过螯合铁或使细菌膜不稳定来发挥抗微生物作用。此外，乳铁蛋白主要通过防止单核细胞释放细胞因子和通过调节免疫细胞的增殖和分化来调节炎症过程。这些活性中的一些与乳铁蛋白以高亲和力结合脂多糖（LPS）的能力有关。事实上，最近的体外研究表明，乳铁蛋白能够与LPS结合蛋白竞争LPS结合，从而防止LPS转移到单核细胞表面存在的CD 14。此外，乳铁蛋白在体内对败血症的预防特性已经得到证实。总的来说，这些观察结果强烈表明乳铁蛋白是调节炎症反应的关键分子之一。
Lactoferrin is an iron-binding glycoprotein found in exocrine secretions of mammals and released from neutrophilic granules during inflammation. This review describes the biological roles of lactoferrin in host defence. Secreted lactoferrin exerts antimicrobial action either by chelation of iron or by destabilization of bacterial membranes. Furthermore, lactoferrin modulates the inflammatory process, mainly by pre venting the release of cytokines from monocytes and by regulating the proliferation and differentiation of immune cells. Some of these activities are related to the ability of lactoferrin to bind lipopolysaccharides (LPS) with high affinity. Indeed, recent in vitro studies indicate that lactoferrin is able to compete with the LPS-binding protein for LPS binding and therefore to prevent the transfer of LPS to CD14 present at the surface of monocytes. Moreover, the prophylactic properties of lactoferrin against septicemia in vivo have been demonstrated. Taken as a whole, these observations strongly suggest that lactoferrin is one of the key molecules which modulate the inflammatory response.