Effect of menstrual cycle and female hormones on TRP and TREK channels in modifying thermosensitivity and physiological functions in women
Effect of menstrual cycle and female hormones on TRP and TREK channels in modifying thermosensitivity and physiological functions in women
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月经周期和女性激素对 TRP 和 TREK 通道改变女性热敏感性和生理功能的影响
DOI：
10.1016/j.jtherbio.2021.103029
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发表时间：
2021
影响因子：
2.7
通讯作者：
Masahiko Izumizaki
中科院分区：
文献类型：
--
作者：
Yuki Uchida;Masahiko Izumizaki
体温调节对人类在各种环境温度下的生存至关重要。感觉神经元中表达的瞬时受体电位（TRP）和与twik相关的K+(TREK)通道在温度检测的外周热敏性中起作用。此外，这些通道在骨骼、神经、免疫、血管、消化和泌尿系统中具有各种生理作用。在女性中，雌性激素雌二醇（E2）和黄体酮（P4）在月经周期中波动，影响各种生理功能，例如在冷热环境下的体温调节。现就雌性激素对TRP和TREK通道的影响及其生理功能作一综述。P4通过TRPV1降低了热敏性。E2促进颞下颌关节疾病（TRPV1）、乳腺癌（TRPM8）和消化系统钙吸收（TRPV5和TRPV6），抑制血管收缩（TRPM3）、神经炎症（TRPM4）、甜味敏感（TRPM5）和月经紊乱（TRPC1）的促进，并通过各通道预防胰岛素抵抗（TRPC5）。P4抑制血管收缩（TRPM3）、甜味敏感性（TRPM5）、肺部纤毛运动（TRPV4）、月经失调（TRPC1）和免疫力（TRPC3），并通过各通道促进乳腺癌（TRPV6）。女性激素对TREK通道和生理功能的影响仍在研究中。综上所述，雌性激素通过一些TRP通道影响生理功能；然而，文献并不全面，需要进一步的研究，特别是与女性体温调节有关的研究。
Thermoregulation is crucial for human survival at various ambient temperatures. Transient receptor potential (TRP) and TWIK-related K+(TREK) channels expressed in sensory neurons play a role in peripheral thermosensitivity for temperature detection. In addition, these channels have various physiological roles in the skeletal, nervous, immune, vascular, digestive, and urinary systems. In women, the female hormones estradiol (E2) and progesterone (P4), which fluctuate during the menstrual cycle, affect various physiological functions, such as thermoregulation in hot and cold environments. The present review describes the effect of female hormones on TRP and TREK channels and related physiological functions. The P4 decreased thermosensitivity via TRPV1. E2 facilitates temporomandibular joint disease (TRPV1), breast cancer (TRPM8), and calcium absorption in the digestive system (TRPV5 and TRPV6), inhibits the facilitation of vasoconstriction (TRPM3), nerve inflammation (TRPM4), sweetness sensitivity (TRPM5), and menstrual disorders (TRPC1), and prevents insulin resistance (TRPC5) via each channel. P4 inhibits vasoconstriction (TRPM3), sweetness sensitivity (TRPM5), ciliary motility in the lungs (TRPV4), menstrual disorder (TRPC1), and immunity (TRPC3), and facilitates breast cancer (TRPV6) via each channel as indicated. The effects of female hormones on TREK channels and physiological functions are still under investigation. In summary, female hormones influence physiological functions via some TRP channels; however, the literature is not comprehensive and future studies are needed, especially those related to thermoregulation in women.