PdII/AgI-Catalyzed Room-Temperature Reaction of γ-Hydroxy Lactams: Mechanism, Scope, and Antistaphylococcal Activity
PdII/AgI-Catalyzed Room-Temperature Reaction of γ-Hydroxy Lactams: Mechanism, Scope, and Antistaphylococcal Activity
复制标题
DOI：
10.1021/acs.joc.6b02378
复制
发表时间：
2017-02-17
影响因子：
3.6
通讯作者：
Pratihar, Sanjay
中科院分区：
文献类型：
--
作者：
Dutta, Manali;Mandal, Santi M.;Pratihar, Sanjay
本文报道了室温下Pd-II/Ag-I促进的γ-羟基内酰胺与C/O/S亲核试剂的酰胺烷基化反应。通过原位生成的催化活性阳离子Pd-II物种活化亲电试剂和亲核试剂的双重模式促进了在室温下的反应。在合成的异吲哚啉衍生物中，发现三个化合物对万古霉素和甲氧西林耐药的S。金黄色葡萄球菌菌株具有可感知的MIC值。
The present work reports a Pd-II/Ag-I-promoted amidoalkylation reaction involving various gamma-hydroxy lactams and C/O/S nucleophiles at room temperature. The dual mode of activation of both the electrophile and nucleophile by in situ generated catalytically active cationic Pd-II species facilitates the reaction at room temperature. Among the synthesized isoindoline derivatives, three compounds are found to be active against vancomycin and methicillin-resistant S. aureus strain with appreciable MIC values.