Influence of protein and lipid concentration of the test lubricant on the wear of ultra high molecular weight polyethylene
Influence of protein and lipid concentration of the test lubricant on the wear of ultra high molecular weight polyethylene
复制标题
DOI：
10.1016/j.triboint.2007.11.010
复制
发表时间：
2008-07
影响因子：
6.2
通讯作者：
Y. Sawae;A. Yamamoto;T. Murakami
中科院分区：
文献类型：
--
作者：
Y. Sawae;A. Yamamoto;T. Murakami
为了更好地了解超高相对分子质量聚乙烯(UHMWPE)在生理环境中的磨损机理，实验研究了滑液中蛋白质和脂肪成分对UHMWPE比磨损率的影响。利用多向滑动销-板磨损试验机模拟髋关节假体的简化滑动条件。分别以牛血清γ-球蛋白和人工合成的L-α-DPPC作为滑膜的模型蛋白和脂组分。磨损试验结果表明，超高相对分子质量聚乙烯的磨损率主要取决于试验润滑剂中蛋白质的浓度。在低蛋白润滑剂中，脂类起到了边界润滑剂的作用，减少了聚乙烯的磨损。然而，当蛋白质浓度在生理水平时，聚乙烯磨损率随脂肪浓度的增加而增加。蛋白质和脂类分子间的相互作用增加和脂类向聚乙烯表面扩散可能是导致磨损量增加的原因。
To gain a better understanding of the ultra-high molecular weight polyethylene (UHMWPE) wear mechanism in the physiological environment, the effects of protein and lipid constituents of synovial fluid on the specific wear rate of UHMWPE were examined experimentally. The multidirectional sliding pin-on-plate wear tester was employed to simulate the simplified sliding condition of hip joint prostheses. Bovine serum γ-globulin and synthetic l-α-DPPC were used as model protein and lipid constituents of synovia, respectively. Results of the wear test indicated that the UHMWPE wear rate primarily depended on the protein concentration of the test lubricant. Lipids acted as a boundary lubricant and reduced polyethylene wear in the low protein lubricants. However, the polyethylene wear rate increased with increasing lipid concentrations if the protein concentration was within the physiological level. Increased interactions between protein and lipid molecules and lipid diffusion to polyethylene surface might be responsible for the increased wear.