Mammary tumor virus (MTV) antigens in normal and mammary tumor‐bearing mice
Mammary tumor virus (MTV) antigens in normal and mammary tumor‐bearing mice
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正常和乳腺肿瘤小鼠的乳腺肿瘤病毒（MTV）抗原
DOI：
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发表时间：
1973
影响因子：
6.4
通讯作者：
R. van Nie
中科院分区：
文献类型：
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作者：
J. Hilgers;G. J. Theuns;R. van Nie
使用定量免疫荧光试验研究了两种低（BALB/c和C3 Hf）和两种高（C3 H和GR）乳腺癌株的正常和乳腺肿瘤荷瘤小鼠中MTV抗原的产生。乳腺肿瘤可根据两组中的MTV抗原表达进行区分;（1）BALB/c小鼠中发生的一组阳性肿瘤和（2）一组阴性肿瘤。第一组肿瘤均为腺癌，第二组肿瘤为腺棘皮瘤。在C3 Hf和C3 H株的肿瘤中，以及在BALB/c株的MTV诱导的肿瘤中，MTV抗原产生相对较高，但在GR株肿瘤中较低。携带MTV抗原的乳腺肿瘤小鼠（以及一些妊娠和哺乳期GR小鼠）的血清中含有过量的MTV抗原。携带MTV抗原诱导的肿瘤的BALB/c小鼠的脾脏通常含有可检测量的MTV抗原，而正常和携带乳腺肿瘤的C3 Hf和C3 H小鼠的脾脏中偶尔也显示出可检测量的MTV抗原。相比之下，GR小鼠的脾脏通过免疫荧光吸收试验始终呈MTV抗原阴性。胸腺，肝脏和肾脏的各种测试菌株都是阴性的。
Quantitative immunofluorescence tests were used to study MTV‐antigen production in normal and mammary tumor‐bearing mice of two low (BALB/c and C3Hf) and two high (C3H and GR) mammary cancer strains. Mammary tumors could be distinguished on the basis of MTV‐antigen expression in two groups; (1) a group of positive and (2) a group of negative tumors occurring in BALB/c mice. While the tumors of the first group in this study were all adenocarcinomas, the tumors of the second group were adenoacanthomas. MTV‐antigen production was comparatively high in tumors of the C3Hf and C3H strains, as well as in the MTV‐induced tumors of the BALB/c strain, but low in GR‐strain tumors. Sera from mice bearing MTV‐antigen producing mammary tumors (as well as from some pregnant and lactating GR mice) contained excess MTV‐antigens. Spleens of BALB/c mice bearing MTV‐antigen‐induced tumors often contained detectable amounts of MTV‐antigens, while normal and mammary tumor‐bearing C3Hf and C3H mice also occasionally showed detectable amounts of MTV‐antigens in their spleens. In contrast, spleens of GR mice were always MTV‐antigen negative by immunofluorescence absorption tests. Thymuses, livers and kidneys of the various strains tested were invariably negative.